Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4718252..4718854 Replicon chromosome
Accession NZ_AP023311
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4596

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag K5674_RS22915 Protein ID WP_001159630.1
Coordinates 4718543..4718854 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K5674_RS22910 Protein ID WP_000362050.1
Coordinates 4718252..4718542 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5674_RS22895 (4715745) 4715745..4716647 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
K5674_RS22900 (4716644) 4716644..4717279 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
K5674_RS22905 (4717276) 4717276..4718205 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
K5674_RS22910 (4718252) 4718252..4718542 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
K5674_RS22915 (4718543) 4718543..4718854 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
K5674_RS22920 (4719072) 4719072..4720001 + 930 WP_001127703.1 alpha/beta hydrolase -
K5674_RS22925 (4720087) 4720087..4720398 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
K5674_RS22930 (4720395) 4720395..4720841 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
K5674_RS22935 (4720856) 4720856..4721797 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
K5674_RS22940 (4721842) 4721842..4722279 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
K5674_RS22945 (4722276) 4722276..4723148 - 873 WP_000921427.1 virulence factor BrkB family protein -
K5674_RS22950 (4723142) 4723142..4723741 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(36-85)


Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T37495 WP_001159630.1 NZ_AP023311:c4718854-4718543 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T37495 NZ_AP023311:c4718854-4718543 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT37495 WP_000362050.1 NZ_AP023311:c4718542-4718252 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT37495 NZ_AP023311:c4718542-4718252 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64


Antitoxin

Source ID Structure

References