Detailed information of TA system TA037470

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4692558..4693160
• Replicon: chromosome
• Accession: NZ_AP023309
• Organism: Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4578

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: K5680_RS22735
• Protein ID: WP_001159630.1
• Coordinates: 4692849..4693160 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: K5680_RS22730
• Protein ID: WP_000362050.1
• Coordinates: 4692558..4692848 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5680_RS22715 (4690051)	4690051..4690953	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
K5680_RS22720 (4690950)	4690950..4691585	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
K5680_RS22725 (4691582)	4691582..4692511	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
K5680_RS22730 (4692558)	4692558..4692848	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
K5680_RS22735 (4692849)	4692849..4693160	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
K5680_RS22740 (4693378)	4693378..4694307	+	930	WP_001127703.1	alpha/beta hydrolase	-
K5680_RS22745 (4694393)	4694393..4694704	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
K5680_RS22750 (4694701)	4694701..4695147	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
K5680_RS22755 (4695162)	4695162..4696103	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
K5680_RS22760 (4696148)	4696148..4696585	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
K5680_RS22765 (4696582)	4696582..4697454	-	873	WP_000921427.1	virulence factor BrkB family protein	-
K5680_RS22770 (4697448)	4697448..4698047	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T37470 WP_001159630.1 NZ_AP023309:c4693160-4692849 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T37470 NZ_AP023309:c4693160-4692849 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT37470 WP_000362050.1 NZ_AP023309:c4692848-4692558 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT37470 NZ_AP023309:c4692848-4692558 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64