Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 364879..365417 Replicon chromosome
Accession NZ_AP023309
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4578

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag K5680_RS01660 Protein ID WP_001526148.1
Coordinates 365142..365417 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag K5680_RS01655 Protein ID WP_000729713.1
Coordinates 364879..365139 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5680_RS01635 (360432) 360432..361985 + 1554 WP_000013007.1 TROVE domain-containing protein -
K5680_RS01640 (361994) 361994..362185 + 192 Protein_324 TROVE domain-containing protein -
K5680_RS01645 (362533) 362533..363747 + 1215 WP_001105521.1 RNA-splicing ligase RtcB -
K5680_RS01650 (363751) 363751..364770 + 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
K5680_RS01655 (364879) 364879..365139 + 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K5680_RS01660 (365142) 365142..365417 + 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
K5680_RS01665 (365505) 365505..368210 - 2706 WP_000907029.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T37450 WP_001526148.1 NZ_AP023309:365142-365417 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T37450 NZ_AP023309:365142-365417 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT37450 WP_000729713.1 NZ_AP023309:364879-365139 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT37450 NZ_AP023309:364879-365139 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References