Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2428253..2428775 Replicon chromosome
Accession NZ_AP023306
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4567

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag K5646_RS11880 Protein ID WP_000221343.1
Coordinates 2428491..2428775 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag K5646_RS11875 Protein ID WP_000885424.1
Coordinates 2428253..2428501 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5646_RS11850 (2423469) 2423469..2424935 + 1467 WP_000987828.1 hypothetical protein -
K5646_RS11855 (2425743) 2425743..2426457 + 715 Protein_2329 helix-turn-helix domain-containing protein -
K5646_RS11860 (2426513) 2426513..2427421 - 909 WP_010989018.1 hypothetical protein -
K5646_RS11865 (2427564) 2427564..2427896 - 333 WP_000253154.1 DUF1493 family protein -
K5646_RS11870 (2427886) 2427886..2428101 - 216 WP_000206207.1 hypothetical protein -
K5646_RS11875 (2428253) 2428253..2428501 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K5646_RS11880 (2428491) 2428491..2428775 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5646_RS11885 (2428946) 2428946..2429335 + 390 WP_000194089.1 RidA family protein -
K5646_RS11890 (2429387) 2429387..2430466 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
K5646_RS11895 (2430659) 2430659..2431147 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
K5646_RS11900 (2431192) 2431192..2432700 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2423472..2435557 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T37429 WP_000221343.1 NZ_AP023306:2428491-2428775 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T37429 NZ_AP023306:2428491-2428775 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT37429 WP_000885424.1 NZ_AP023306:2428253-2428501 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT37429 NZ_AP023306:2428253-2428501 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References