Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4820154..4820908 Replicon chromosome
Accession NZ_AP023303
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4526

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag K5618_RS23580 Protein ID WP_000558166.1
Coordinates 4820154..4820465 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K5618_RS23585 Protein ID WP_001259011.1
Coordinates 4820462..4820908 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5618_RS23550 (4815812) 4815812..4816714 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
K5618_RS23555 (4816711) 4816711..4817346 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
K5618_RS23560 (4817343) 4817343..4818272 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
K5618_RS23565 (4818319) 4818319..4818609 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
K5618_RS23570 (4818610) 4818610..4818921 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
K5618_RS23575 (4819139) 4819139..4820068 + 930 WP_001127703.1 alpha/beta hydrolase -
K5618_RS23580 (4820154) 4820154..4820465 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
K5618_RS23585 (4820462) 4820462..4820908 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
K5618_RS23590 (4820923) 4820923..4821864 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
K5618_RS23595 (4821909) 4821909..4822346 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
K5618_RS23600 (4822343) 4822343..4823215 - 873 WP_000921427.1 virulence factor BrkB family protein -
K5618_RS23605 (4823209) 4823209..4823808 - 600 WP_000965695.1 glucose-1-phosphatase -
K5618_RS23610 (4823999) 4823999..4824802 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
K5618_RS23615 (4824836) 4824836..4825732 - 897 WP_001520529.1 sugar kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T37389 WP_000558166.1 NZ_AP023303:4820154-4820465 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T37389 NZ_AP023303:4820154-4820465 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT37389 WP_001259011.1 NZ_AP023303:4820462-4820908 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT37389 NZ_AP023303:4820462-4820908 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90


Antitoxin

Source ID Structure

References