Detailed information of TA system TA037388

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4818319..4818921
• Replicon: chromosome
• Accession: NZ_AP023303
• Organism: Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4526

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: K5618_RS23570
• Protein ID: WP_001159630.1
• Coordinates: 4818610..4818921 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: K5618_RS23565
• Protein ID: WP_000362050.1
• Coordinates: 4818319..4818609 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5618_RS23550 (4815812)	4815812..4816714	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
K5618_RS23555 (4816711)	4816711..4817346	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
K5618_RS23560 (4817343)	4817343..4818272	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
K5618_RS23565 (4818319)	4818319..4818609	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
K5618_RS23570 (4818610)	4818610..4818921	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
K5618_RS23575 (4819139)	4819139..4820068	+	930	WP_001127703.1	alpha/beta hydrolase	-
K5618_RS23580 (4820154)	4820154..4820465	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
K5618_RS23585 (4820462)	4820462..4820908	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
K5618_RS23590 (4820923)	4820923..4821864	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
K5618_RS23595 (4821909)	4821909..4822346	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
K5618_RS23600 (4822343)	4822343..4823215	-	873	WP_000921427.1	virulence factor BrkB family protein	-
K5618_RS23605 (4823209)	4823209..4823808	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T37388 WP_001159630.1 NZ_AP023303:c4818921-4818610 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T37388 NZ_AP023303:c4818921-4818610 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT37388 WP_000362050.1 NZ_AP023303:c4818609-4818319 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT37388 NZ_AP023303:c4818609-4818319 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64