Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 4719976..4720578 | Replicon | chromosome |
Accession | NZ_AP023300 | ||
Organism | Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4445 |
Toxin (Protein)
Gene name | higB | Uniprot ID | C0Q3J8 |
Locus tag | K5630_RS22915 | Protein ID | WP_001159630.1 |
Coordinates | 4720267..4720578 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | K5630_RS22910 | Protein ID | WP_000362050.1 |
Coordinates | 4719976..4720266 (-) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K5630_RS22895 (4717469) | 4717469..4718371 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
K5630_RS22900 (4718368) | 4718368..4719003 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
K5630_RS22905 (4719000) | 4719000..4719929 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
K5630_RS22910 (4719976) | 4719976..4720266 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | Antitoxin |
K5630_RS22915 (4720267) | 4720267..4720578 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | Toxin |
K5630_RS22920 (4720796) | 4720796..4721725 | + | 930 | WP_001127703.1 | alpha/beta hydrolase | - |
K5630_RS22925 (4721811) | 4721811..4722122 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | - |
K5630_RS22930 (4722119) | 4722119..4722565 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | - |
K5630_RS22935 (4722580) | 4722580..4723521 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
K5630_RS22940 (4723566) | 4723566..4724003 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
K5630_RS22945 (4724000) | 4724000..4724872 | - | 873 | WP_000921427.1 | virulence factor BrkB family protein | - |
K5630_RS22950 (4724866) | 4724866..4725465 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12326.27 Da Isoelectric Point: 9.4460
>T37360 WP_001159630.1 NZ_AP023300:c4720578-4720267 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
Download Length: 312 bp
>T37360 NZ_AP023300:c4720578-4720267 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
Antitoxin
Download Length: 97 a.a. Molecular weight: 10971.59 Da Isoelectric Point: 10.6525
>AT37360 WP_000362050.1 NZ_AP023300:c4720266-4719976 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY
Download Length: 291 bp
>AT37360 NZ_AP023300:c4720266-4719976 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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