37352

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2428255..2428777 Replicon chromosome
Accession NZ_AP023300
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4445

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag K5630_RS11880 Protein ID WP_000221343.1
Coordinates 2428493..2428777 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag K5630_RS11875 Protein ID WP_000885424.1
Coordinates 2428255..2428503 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5630_RS11850 (2423471) 2423471..2424937 + 1467 WP_000987828.1 hypothetical protein -
K5630_RS11855 (2425745) 2425745..2426459 + 715 Protein_2330 helix-turn-helix domain-containing protein -
K5630_RS11860 (2426515) 2426515..2427423 - 909 WP_010989018.1 hypothetical protein -
K5630_RS11865 (2427566) 2427566..2427898 - 333 WP_000253154.1 DUF1493 family protein -
K5630_RS11870 (2427888) 2427888..2428103 - 216 WP_000206207.1 hypothetical protein -
K5630_RS11875 (2428255) 2428255..2428503 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K5630_RS11880 (2428493) 2428493..2428777 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5630_RS11885 (2428948) 2428948..2429337 + 390 WP_000194089.1 RidA family protein -
K5630_RS11890 (2429389) 2429389..2430468 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
K5630_RS11895 (2430661) 2430661..2431149 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
K5630_RS11900 (2431194) 2431194..2432702 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2423474..2435559 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T37352 WP_000221343.1 NZ_AP023300:2428493-2428777 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T37352 NZ_AP023300:2428493-2428777 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT37352 WP_000885424.1 NZ_AP023300:2428255-2428503 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT37352 NZ_AP023300:2428255-2428503 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References