Detailed information of TA system TA037336

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4720002..4720604
• Replicon: chromosome
• Accession: NZ_AP023299
• Organism: Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4334

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: K5616_RS22915
• Protein ID: WP_001159630.1
• Coordinates: 4720293..4720604 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: K5616_RS22910
• Protein ID: WP_000362050.1
• Coordinates: 4720002..4720292 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5616_RS22895 (4717495)	4717495..4718397	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
K5616_RS22900 (4718394)	4718394..4719029	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
K5616_RS22905 (4719026)	4719026..4719955	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
K5616_RS22910 (4720002)	4720002..4720292	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
K5616_RS22915 (4720293)	4720293..4720604	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
K5616_RS22920 (4720822)	4720822..4721751	+	930	WP_001127703.1	alpha/beta hydrolase	-
K5616_RS22925 (4721837)	4721837..4722148	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
K5616_RS22930 (4722145)	4722145..4722591	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
K5616_RS22935 (4722606)	4722606..4723547	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
K5616_RS22940 (4723592)	4723592..4724029	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
K5616_RS22945 (4724026)	4724026..4724898	-	873	WP_000921427.1	virulence factor BrkB family protein	-
K5616_RS22950 (4724892)	4724892..4725491	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T37336 WP_001159630.1 NZ_AP023299:c4720604-4720293 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T37336 NZ_AP023299:c4720604-4720293 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT37336 WP_000362050.1 NZ_AP023299:c4720292-4720002 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT37336 NZ_AP023299:c4720292-4720002 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64