37328

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2428276..2428798 Replicon chromosome
Accession NZ_AP023299
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4334

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag K5616_RS11880 Protein ID WP_000221343.1
Coordinates 2428514..2428798 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag K5616_RS11875 Protein ID WP_000885424.1
Coordinates 2428276..2428524 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5616_RS11850 (2423492) 2423492..2424958 + 1467 WP_000987828.1 hypothetical protein -
K5616_RS11855 (2425766) 2425766..2426480 + 715 Protein_2328 helix-turn-helix domain-containing protein -
K5616_RS11860 (2426536) 2426536..2427444 - 909 WP_010989018.1 hypothetical protein -
K5616_RS11865 (2427587) 2427587..2427919 - 333 WP_000253154.1 DUF1493 family protein -
K5616_RS11870 (2427909) 2427909..2428124 - 216 WP_000206207.1 hypothetical protein -
K5616_RS11875 (2428276) 2428276..2428524 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K5616_RS11880 (2428514) 2428514..2428798 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5616_RS11885 (2428969) 2428969..2429358 + 390 WP_000194089.1 RidA family protein -
K5616_RS11890 (2429410) 2429410..2430489 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
K5616_RS11895 (2430682) 2430682..2431170 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
K5616_RS11900 (2431215) 2431215..2432723 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2423495..2435580 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T37328 WP_000221343.1 NZ_AP023299:2428514-2428798 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T37328 NZ_AP023299:2428514-2428798 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT37328 WP_000885424.1 NZ_AP023299:2428276-2428524 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT37328 NZ_AP023299:2428276-2428524 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References