Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4720259..4721013 Replicon chromosome
Accession NZ_AP023294
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4261

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag K5635_RS22935 Protein ID WP_000558166.1
Coordinates 4720259..4720570 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K5635_RS22940 Protein ID WP_001259011.1
Coordinates 4720567..4721013 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5635_RS22905 (4715917) 4715917..4716819 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
K5635_RS22910 (4716816) 4716816..4717451 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
K5635_RS22915 (4717448) 4717448..4718377 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
K5635_RS22920 (4718424) 4718424..4718714 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
K5635_RS22925 (4718715) 4718715..4719026 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
K5635_RS22930 (4719244) 4719244..4720173 + 930 WP_001127703.1 alpha/beta hydrolase -
K5635_RS22935 (4720259) 4720259..4720570 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
K5635_RS22940 (4720567) 4720567..4721013 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
K5635_RS22945 (4721028) 4721028..4721969 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
K5635_RS22950 (4722014) 4722014..4722451 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
K5635_RS22955 (4722448) 4722448..4723320 - 873 WP_000921427.1 virulence factor BrkB family protein -
K5635_RS22960 (4723314) 4723314..4723913 - 600 WP_000965695.1 glucose-1-phosphatase -
K5635_RS22965 (4724104) 4724104..4724907 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
K5635_RS22970 (4724941) 4724941..4725837 - 897 WP_001520529.1 sugar kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T37312 WP_000558166.1 NZ_AP023294:4720259-4720570 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T37312 NZ_AP023294:4720259-4720570 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT37312 WP_001259011.1 NZ_AP023294:4720567-4721013 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT37312 NZ_AP023294:4720567-4721013 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90


Antitoxin

Source ID Structure

References