Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2428144..2428666 Replicon chromosome
Accession NZ_AP023294
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4261

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag K5635_RS11875 Protein ID WP_000221343.1
Coordinates 2428382..2428666 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag K5635_RS11870 Protein ID WP_000885424.1
Coordinates 2428144..2428392 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5635_RS11845 (2423360) 2423360..2424826 + 1467 WP_000987828.1 hypothetical protein -
K5635_RS11850 (2425634) 2425634..2426348 + 715 Protein_2329 helix-turn-helix domain-containing protein -
K5635_RS11855 (2426404) 2426404..2427312 - 909 WP_010989018.1 hypothetical protein -
K5635_RS11860 (2427455) 2427455..2427787 - 333 WP_000253154.1 DUF1493 family protein -
K5635_RS11865 (2427777) 2427777..2427992 - 216 WP_000206207.1 hypothetical protein -
K5635_RS11870 (2428144) 2428144..2428392 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K5635_RS11875 (2428382) 2428382..2428666 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5635_RS11880 (2428837) 2428837..2429226 + 390 WP_000194089.1 RidA family protein -
K5635_RS11885 (2429278) 2429278..2430357 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
K5635_RS11890 (2430550) 2430550..2431038 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
K5635_RS11895 (2431083) 2431083..2432591 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2423363..2435448 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T37303 WP_000221343.1 NZ_AP023294:2428382-2428666 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T37303 NZ_AP023294:2428382-2428666 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT37303 WP_000885424.1 NZ_AP023294:2428144-2428392 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT37303 NZ_AP023294:2428144-2428392 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References