37255

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2455342..2455864 Replicon chromosome
Accession NZ_AP023291
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain L-4126

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag K5613_RS11980 Protein ID WP_000221343.1
Coordinates 2455580..2455864 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag K5613_RS11975 Protein ID WP_000885424.1
Coordinates 2455342..2455590 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5613_RS11950 (2450558) 2450558..2452024 + 1467 WP_000987828.1 hypothetical protein -
K5613_RS11955 (2452832) 2452832..2453546 + 715 Protein_2350 helix-turn-helix domain-containing protein -
K5613_RS11960 (2453602) 2453602..2454510 - 909 WP_010989018.1 hypothetical protein -
K5613_RS11965 (2454653) 2454653..2454985 - 333 WP_000253154.1 DUF1493 family protein -
K5613_RS11970 (2454975) 2454975..2455190 - 216 WP_000206207.1 hypothetical protein -
K5613_RS11975 (2455342) 2455342..2455590 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K5613_RS11980 (2455580) 2455580..2455864 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5613_RS11985 (2456035) 2456035..2456424 + 390 WP_000194089.1 RidA family protein -
K5613_RS11990 (2456476) 2456476..2457555 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
K5613_RS11995 (2457748) 2457748..2458236 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
K5613_RS12000 (2458281) 2458281..2459789 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2450561..2462646 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T37255 WP_000221343.1 NZ_AP023291:2455580-2455864 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T37255 NZ_AP023291:2455580-2455864 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT37255 WP_000885424.1 NZ_AP023291:2455342-2455590 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT37255 NZ_AP023291:2455342-2455590 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References