Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4803697..4804451 Replicon chromosome
Accession NZ_AP023289
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3837

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag K5612_RS23465 Protein ID WP_000558166.1
Coordinates 4803697..4804008 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K5612_RS23470 Protein ID WP_001259011.1
Coordinates 4804005..4804451 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5612_RS23435 (4799355) 4799355..4800257 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
K5612_RS23440 (4800254) 4800254..4800889 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
K5612_RS23445 (4800886) 4800886..4801815 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
K5612_RS23450 (4801862) 4801862..4802152 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
K5612_RS23455 (4802153) 4802153..4802464 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
K5612_RS23460 (4802682) 4802682..4803611 + 930 WP_001127703.1 alpha/beta hydrolase -
K5612_RS23465 (4803697) 4803697..4804008 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
K5612_RS23470 (4804005) 4804005..4804451 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
K5612_RS23475 (4804466) 4804466..4805407 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
K5612_RS23480 (4805452) 4805452..4805889 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
K5612_RS23485 (4805886) 4805886..4806758 - 873 WP_000921427.1 virulence factor BrkB family protein -
K5612_RS23490 (4806752) 4806752..4807351 - 600 WP_000965695.1 glucose-1-phosphatase -
K5612_RS23495 (4807542) 4807542..4808345 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
K5612_RS23500 (4808379) 4808379..4809275 - 897 WP_001520529.1 sugar kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T37216 WP_000558166.1 NZ_AP023289:4803697-4804008 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T37216 NZ_AP023289:4803697-4804008 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT37216 WP_001259011.1 NZ_AP023289:4804005-4804451 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT37216 NZ_AP023289:4804005-4804451 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90


Antitoxin

Source ID Structure

References