Detailed information of TA system TA037215

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4801862..4802464
• Replicon: chromosome
• Accession: NZ_AP023289
• Organism: Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3837

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: K5612_RS23455
• Protein ID: WP_001159630.1
• Coordinates: 4802153..4802464 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: K5612_RS23450
• Protein ID: WP_000362050.1
• Coordinates: 4801862..4802152 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5612_RS23435 (4799355)	4799355..4800257	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
K5612_RS23440 (4800254)	4800254..4800889	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
K5612_RS23445 (4800886)	4800886..4801815	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
K5612_RS23450 (4801862)	4801862..4802152	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
K5612_RS23455 (4802153)	4802153..4802464	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
K5612_RS23460 (4802682)	4802682..4803611	+	930	WP_001127703.1	alpha/beta hydrolase	-
K5612_RS23465 (4803697)	4803697..4804008	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
K5612_RS23470 (4804005)	4804005..4804451	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
K5612_RS23475 (4804466)	4804466..4805407	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
K5612_RS23480 (4805452)	4805452..4805889	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
K5612_RS23485 (4805886)	4805886..4806758	-	873	WP_000921427.1	virulence factor BrkB family protein	-
K5612_RS23490 (4806752)	4806752..4807351	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T37215 WP_001159630.1 NZ_AP023289:c4802464-4802153 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T37215 NZ_AP023289:c4802464-4802153 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT37215 WP_000362050.1 NZ_AP023289:c4802152-4801862 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT37215 NZ_AP023289:c4802152-4801862 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64