Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2550240..2550762 Replicon chromosome
Accession NZ_AP023289
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3837

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag K5612_RS12540 Protein ID WP_000221343.1
Coordinates 2550478..2550762 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag K5612_RS12535 Protein ID WP_000885424.1
Coordinates 2550240..2550488 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5612_RS12510 (2545456) 2545456..2546922 + 1467 WP_000987828.1 hypothetical protein -
K5612_RS12515 (2547730) 2547730..2548444 + 715 Protein_2463 helix-turn-helix domain-containing protein -
K5612_RS12520 (2548500) 2548500..2549408 - 909 WP_010989018.1 hypothetical protein -
K5612_RS12525 (2549551) 2549551..2549883 - 333 WP_000253154.1 DUF1493 family protein -
K5612_RS12530 (2549873) 2549873..2550088 - 216 WP_000206207.1 hypothetical protein -
K5612_RS12535 (2550240) 2550240..2550488 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K5612_RS12540 (2550478) 2550478..2550762 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5612_RS12545 (2550933) 2550933..2551322 + 390 WP_000194089.1 RidA family protein -
K5612_RS12550 (2551374) 2551374..2552453 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
K5612_RS12555 (2552646) 2552646..2553134 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
K5612_RS12560 (2553179) 2553179..2554687 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2545459..2557544 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T37207 WP_000221343.1 NZ_AP023289:2550478-2550762 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T37207 NZ_AP023289:2550478-2550762 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT37207 WP_000885424.1 NZ_AP023289:2550240-2550488 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT37207 NZ_AP023289:2550240-2550488 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References