Detailed information of TA system TA037191

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4798103..4798705
• Replicon: chromosome
• Accession: NZ_AP023288
• Organism: Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3835

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: K5610_RS23500
• Protein ID: WP_001159630.1
• Coordinates: 4798394..4798705 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: K5610_RS23495
• Protein ID: WP_000362050.1
• Coordinates: 4798103..4798393 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5610_RS23480 (4795596)	4795596..4796498	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
K5610_RS23485 (4796495)	4796495..4797130	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
K5610_RS23490 (4797127)	4797127..4798056	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
K5610_RS23495 (4798103)	4798103..4798393	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
K5610_RS23500 (4798394)	4798394..4798705	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
K5610_RS23505 (4798923)	4798923..4799852	+	930	WP_001127703.1	alpha/beta hydrolase	-
K5610_RS23510 (4799938)	4799938..4800249	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
K5610_RS23515 (4800246)	4800246..4800692	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
K5610_RS23520 (4800707)	4800707..4801648	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
K5610_RS23525 (4801693)	4801693..4802130	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
K5610_RS23530 (4802127)	4802127..4802999	-	873	WP_000921427.1	virulence factor BrkB family protein	-
K5610_RS23535 (4802993)	4802993..4803592	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T37191 WP_001159630.1 NZ_AP023288:c4798705-4798394 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T37191 NZ_AP023288:c4798705-4798394 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT37191 WP_000362050.1 NZ_AP023288:c4798393-4798103 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT37191 NZ_AP023288:c4798393-4798103 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64