Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1540385..1541061 Replicon chromosome
Accession NZ_AP023287
Organism Mycolicibacterium litorale strain NIIDNTM18

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NIIDNTM18_RS07395 Protein ID WP_185295071.1
Coordinates 1540711..1541061 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIIDNTM18_RS07390 Protein ID WP_185295070.1
Coordinates 1540385..1540708 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIIDNTM18_RS07375 1536089..1537476 + 1388 Protein_1466 FAD-binding oxidoreductase -
NIIDNTM18_RS07385 1538208..1540184 - 1977 WP_185295069.1 hypothetical protein -
NIIDNTM18_RS07390 1540385..1540708 - 324 WP_185295070.1 XRE family transcriptional regulator Antitoxin
NIIDNTM18_RS07395 1540711..1541061 - 351 WP_185295071.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIIDNTM18_RS07400 1541097..1542295 - 1199 Protein_1470 site-specific integrase -
NIIDNTM18_RS07405 1542299..1542442 - 144 Protein_1471 Arm DNA-binding domain-containing protein -
NIIDNTM18_RS07410 1542439..1542624 - 186 WP_197973406.1 helix-turn-helix domain-containing protein -
NIIDNTM18_RS07415 1543094..1545883 + 2790 WP_185295073.1 relaxase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(33-95)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13074.77 Da        Isoelectric Point: 4.8616

>T37167 WP_185295071.1 NZ_AP023287:c1541061-1540711 [Mycolicibacterium litorale]
MAWVVLLLEEVERWYFSLDDDTMTSVTGAIDLLEAEGPSLGRPTVDRVNGSTFHNMKELRPAGTSVRILFIFDPHRQAIL
LLGGDKAGNWRSWYDKNIPVADERYARWLATGHGGD

Download         Length: 351 bp

>T37167 NZ_AP023287:c1541061-1540711 [Mycolicibacterium litorale]
ATGGCGTGGGTGGTGCTCCTGCTGGAGGAGGTCGAACGGTGGTACTTCTCGCTGGACGACGACACCATGACGTCGGTGAC
CGGTGCGATCGACTTACTCGAGGCGGAGGGGCCCTCCCTCGGCCGGCCGACGGTGGACCGGGTGAACGGCTCGACGTTCC
ACAACATGAAGGAACTGCGTCCCGCCGGTACGAGCGTCCGCATCTTGTTCATCTTCGATCCGCACCGCCAGGCGATCCTG
CTGCTCGGCGGCGACAAAGCCGGAAACTGGCGAAGCTGGTACGACAAGAACATCCCGGTCGCGGACGAGCGTTACGCCAG
ATGGCTGGCGACCGGTCACGGAGGTGATTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11638.01 Da        Isoelectric Point: 6.0833

>AT37167 WP_185295070.1 NZ_AP023287:c1540708-1540385 [Mycolicibacterium litorale]
MARNWREIRAEAVEQGRVDPARADSARKEMHEAVQAYRLAEIRKAHGHARQADVAALMGVSQARVSQLESGDLAHTELGT
LQSYVAALGGQLRIVADFGEDSVELTA

Download         Length: 324 bp

>AT37167 NZ_AP023287:c1540708-1540385 [Mycolicibacterium litorale]
ATGGCGCGCAATTGGCGTGAGATCCGAGCTGAGGCGGTGGAACAAGGTCGCGTCGACCCGGCGCGCGCGGACTCGGCACG
CAAGGAGATGCACGAAGCCGTCCAGGCCTATCGTCTCGCCGAGATTCGTAAGGCGCACGGTCACGCACGCCAGGCCGACG
TTGCGGCGCTCATGGGCGTCTCGCAGGCTCGGGTGTCGCAATTGGAGAGCGGCGACCTGGCGCATACGGAACTGGGCACG
CTGCAGTCTTACGTCGCCGCCCTCGGCGGGCAACTGCGGATCGTGGCCGATTTCGGGGAGGACAGCGTCGAGTTGACGGC
TTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References