Detailed information of TA system TA037167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1540385..1541061
• Replicon: chromosome
• Accession: NZ_AP023287
• Organism: Mycolicibacterium litorale strain NIIDNTM18

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: NIIDNTM18_RS07395
• Protein ID: WP_185295071.1
• Coordinates: 1540711..1541061 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: NIIDNTM18_RS07390
• Protein ID: WP_185295070.1
• Coordinates: 1540385..1540708 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NIIDNTM18_RS07375	1536089..1537476	+	1388	Protein_1466	FAD-binding oxidoreductase	-
NIIDNTM18_RS07385	1538208..1540184	-	1977	WP_185295069.1	hypothetical protein	-
NIIDNTM18_RS07390	1540385..1540708	-	324	WP_185295070.1	XRE family transcriptional regulator	Antitoxin
NIIDNTM18_RS07395	1540711..1541061	-	351	WP_185295071.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NIIDNTM18_RS07400	1541097..1542295	-	1199	Protein_1470	site-specific integrase	-
NIIDNTM18_RS07405	1542299..1542442	-	144	Protein_1471	Arm DNA-binding domain-containing protein	-
NIIDNTM18_RS07410	1542439..1542624	-	186	WP_197973406.1	helix-turn-helix domain-containing protein	-
NIIDNTM18_RS07415	1543094..1545883	+	2790	WP_185295073.1	relaxase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-105)

Antitoxin

• HigA2-like, helix-turn-helix domain (33-95)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13074.77 Da
• Isoelectric Point: 4.8616

>T37167 WP_185295071.1 NZ_AP023287:c1541061-1540711 [Mycolicibacterium litorale]
MAWVVLLLEEVERWYFSLDDDTMTSVTGAIDLLEAEGPSLGRPTVDRVNGSTFHNMKELRPAGTSVRILFIFDPHRQAIL
LLGGDKAGNWRSWYDKNIPVADERYARWLATGHGGD

Nucleotide

• Length: 351 bp

>T37167 NZ_AP023287:c1541061-1540711 [Mycolicibacterium litorale]
ATGGCGTGGGTGGTGCTCCTGCTGGAGGAGGTCGAACGGTGGTACTTCTCGCTGGACGACGACACCATGACGTCGGTGAC
CGGTGCGATCGACTTACTCGAGGCGGAGGGGCCCTCCCTCGGCCGGCCGACGGTGGACCGGGTGAACGGCTCGACGTTCC
ACAACATGAAGGAACTGCGTCCCGCCGGTACGAGCGTCCGCATCTTGTTCATCTTCGATCCGCACCGCCAGGCGATCCTG
CTGCTCGGCGGCGACAAAGCCGGAAACTGGCGAAGCTGGTACGACAAGAACATCCCGGTCGCGGACGAGCGTTACGCCAG
ATGGCTGGCGACCGGTCACGGAGGTGATTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11638.01 Da
• Isoelectric Point: 6.0833

>AT37167 WP_185295070.1 NZ_AP023287:c1540708-1540385 [Mycolicibacterium litorale]
MARNWREIRAEAVEQGRVDPARADSARKEMHEAVQAYRLAEIRKAHGHARQADVAALMGVSQARVSQLESGDLAHTELGT
LQSYVAALGGQLRIVADFGEDSVELTA

Nucleotide

• Length: 324 bp

>AT37167 NZ_AP023287:c1540708-1540385 [Mycolicibacterium litorale]
ATGGCGCGCAATTGGCGTGAGATCCGAGCTGAGGCGGTGGAACAAGGTCGCGTCGACCCGGCGCGCGCGGACTCGGCACG
CAAGGAGATGCACGAAGCCGTCCAGGCCTATCGTCTCGCCGAGATTCGTAAGGCGCACGGTCACGCACGCCAGGCCGACG
TTGCGGCGCTCATGGGCGTCTCGCAGGCTCGGGTGTCGCAATTGGAGAGCGGCGACCTGGCGCATACGGAACTGGGCACG
CTGCAGTCTTACGTCGCCGCCCTCGGCGGGCAACTGCGGATCGTGGCCGATTTCGGGGAGGACAGCGTCGAGTTGACGGC
TTGA