Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2085336..2085978 Replicon chromosome
Accession NZ_AP023213
Organism Geobacter bremensis strain R4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GEOBRER4_RS09300 Protein ID WP_185245160.1
Coordinates 2085336..2085662 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GEOBRER4_RS09305 Protein ID WP_185245161.1
Coordinates 2085655..2085978 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEOBRER4_RS09280 2081532..2082140 - 609 WP_185245156.1 hypothetical protein -
GEOBRER4_RS09285 2082545..2084416 + 1872 WP_185245157.1 cytochrome c3 family protein -
GEOBRER4_RS09290 2084512..2084691 + 180 WP_185245158.1 hypothetical protein -
GEOBRER4_RS09295 2084756..2085289 + 534 WP_185245159.1 MerR family transcriptional regulator -
GEOBRER4_RS09300 2085336..2085662 + 327 WP_185245160.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GEOBRER4_RS09305 2085655..2085978 + 324 WP_185245161.1 helix-turn-helix transcriptional regulator Antitoxin
GEOBRER4_RS09310 2086065..2087141 + 1077 WP_185245307.1 DMT family transporter -
GEOBRER4_RS09315 2087233..2088549 + 1317 WP_185245162.1 cytochrome ubiquinol oxidase subunit I -
GEOBRER4_RS09320 2088542..2089549 + 1008 WP_185245163.1 cytochrome d ubiquinol oxidase subunit II -
GEOBRER4_RS09325 2089747..2090202 + 456 WP_185245164.1 SRPBCC domain-containing protein -
GEOBRER4_RS09330 2090317..2090844 + 528 WP_185245165.1 PaaI family thioesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2071775..2085978 14203


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-96)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12589.66 Da        Isoelectric Point: 9.5444

>T36885 WP_185245160.1 NZ_AP023213:2085336-2085662 [Geobacter bremensis]
MNYIIEYFHARVLDEIESWPDGILADYARILELLMEFGPNLRMPHSRSMGGGIFEVRPRGREGIGRAFYCFQIGQRIIIL
HAFIKKTQATPEQELKLARRRLKEVQNG

Download         Length: 327 bp

>T36885 NZ_AP023213:2085336-2085662 [Geobacter bremensis]
ATGAATTACATCATCGAATATTTCCATGCTCGCGTTCTTGACGAGATTGAATCCTGGCCTGACGGCATTCTTGCCGATTA
TGCAAGGATCCTCGAACTGCTGATGGAATTCGGGCCTAATCTCCGGATGCCTCATTCACGATCGATGGGCGGTGGCATCT
TTGAGGTGCGTCCGCGAGGTCGTGAAGGAATCGGTCGAGCATTCTATTGTTTTCAAATTGGGCAACGGATCATCATACTG
CATGCATTTATTAAAAAGACGCAAGCCACACCGGAGCAGGAATTGAAGCTAGCCCGGAGAAGATTGAAGGAGGTTCAAAA
TGGCTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11892.74 Da        Isoelectric Point: 9.3861

>AT36885 WP_185245161.1 NZ_AP023213:2085655-2085978 [Geobacter bremensis]
MADLKYRPVAHDHKAFLKKANKRDGFKKAYDELEEEYALAKEMLAARARVGLSQEAVAEIMGTTKSAISRLEAVGKHAPS
LTTLKKYAQAVGCHLEIKFVPEHAQPE

Download         Length: 324 bp

>AT36885 NZ_AP023213:2085655-2085978 [Geobacter bremensis]
ATGGCTGACCTAAAATATCGACCGGTTGCACATGACCATAAGGCTTTCCTCAAAAAAGCAAACAAAAGAGATGGTTTCAA
AAAAGCTTACGATGAATTAGAAGAAGAATATGCCTTGGCAAAAGAGATGCTTGCTGCCCGGGCAAGAGTAGGGCTATCAC
AGGAAGCCGTCGCAGAAATTATGGGAACAACAAAGAGTGCAATCTCAAGACTGGAAGCAGTCGGTAAGCACGCCCCTTCT
TTGACTACACTCAAGAAATACGCACAGGCAGTCGGCTGCCATCTTGAGATTAAATTTGTTCCTGAGCATGCCCAACCGGA
ATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References