Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2085336..2085978 Replicon chromosome
Accession NZ_AP023213
Organism Geobacter bremensis strain R4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GEOBRER4_RS09300 Protein ID WP_185245160.1
Coordinates 2085336..2085662 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GEOBRER4_RS09305 Protein ID WP_185245161.1
Coordinates 2085655..2085978 (+) Length 108 a.a.

Genomic Context

GEOBRER4_RS09285GEOBRER4_RS09290GEOBRER4_RS09295GEOBRER4_RS09300GEOBRER4_RS09305GEOBRER4_RS09310GEOBRER4_RS09315GEOBRER4_RS09320GEOBRER4_RS09325GEOBRER4_RS09330GEOBRER4_RS09280
Location: 2082545..2084416 (1872 bp)
Type: Others
Protein ID: WP_185245157.1
Location: 2084512..2084691 (180 bp)
Type: Others
Protein ID: WP_185245158.1
Location: 2084756..2085289 (534 bp)
Type: Others
Protein ID: WP_185245159.1
Location: 2085336..2085662 (327 bp)
Type: Toxin
Protein ID: WP_185245160.1
Location: 2085655..2085978 (324 bp)
Type: Antitoxin
Protein ID: WP_185245161.1
Location: 2086065..2087141 (1077 bp)
Type: Others
Protein ID: WP_185245307.1
Location: 2087233..2088549 (1317 bp)
Type: Others
Protein ID: WP_185245162.1
Location: 2088542..2089549 (1008 bp)
Type: Others
Protein ID: WP_185245163.1
Location: 2089747..2090202 (456 bp)
Type: Others
Protein ID: WP_185245164.1
Location: 2090317..2090844 (528 bp)
Type: Others
Protein ID: WP_185245165.1
Location: 2081532..2082140 (609 bp)
Type: Others
Protein ID: WP_185245156.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GEOBRER4_RS092802081532..2082140-609WP_185245156.1hypothetical protein-
GEOBRER4_RS092852082545..2084416+1872WP_185245157.1cytochrome c3 family protein-
GEOBRER4_RS092902084512..2084691+180WP_185245158.1hypothetical protein-
GEOBRER4_RS092952084756..2085289+534WP_185245159.1MerR family transcriptional regulator-
GEOBRER4_RS093002085336..2085662+327WP_185245160.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GEOBRER4_RS093052085655..2085978+324WP_185245161.1helix-turn-helix transcriptional regulatorAntitoxin
GEOBRER4_RS093102086065..2087141+1077WP_185245307.1DMT family transporter-
GEOBRER4_RS093152087233..2088549+1317WP_185245162.1cytochrome ubiquinol oxidase subunit I-
GEOBRER4_RS093202088542..2089549+1008WP_185245163.1cytochrome d ubiquinol oxidase subunit II-
GEOBRER4_RS093252089747..2090202+456WP_185245164.1SRPBCC domain-containing protein-
GEOBRER4_RS093302090317..2090844+528WP_185245165.1PaaI family thioesterase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--2071775..208597814203


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-96)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12589.66 Da        Isoelectric Point: 9.5444

>T36885 WP_185245160.1 NZ_AP023213:2085336-2085662 [Geobacter bremensis]
MNYIIEYFHARVLDEIESWPDGILADYARILELLMEFGPNLRMPHSRSMGGGIFEVRPRGREGIGRAFYCFQIGQRIIIL
HAFIKKTQATPEQELKLARRRLKEVQNG

Download         Length: 327 bp

>T36885 NZ_AP023213:2085336-2085662 [Geobacter bremensis]
ATGAATTACATCATCGAATATTTCCATGCTCGCGTTCTTGACGAGATTGAATCCTGGCCTGACGGCATTCTTGCCGATTA
TGCAAGGATCCTCGAACTGCTGATGGAATTCGGGCCTAATCTCCGGATGCCTCATTCACGATCGATGGGCGGTGGCATCT
TTGAGGTGCGTCCGCGAGGTCGTGAAGGAATCGGTCGAGCATTCTATTGTTTTCAAATTGGGCAACGGATCATCATACTG
CATGCATTTATTAAAAAGACGCAAGCCACACCGGAGCAGGAATTGAAGCTAGCCCGGAGAAGATTGAAGGAGGTTCAAAA
TGGCTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11892.74 Da        Isoelectric Point: 9.3861

>AT36885 WP_185245161.1 NZ_AP023213:2085655-2085978 [Geobacter bremensis]
MADLKYRPVAHDHKAFLKKANKRDGFKKAYDELEEEYALAKEMLAARARVGLSQEAVAEIMGTTKSAISRLEAVGKHAPS
LTTLKKYAQAVGCHLEIKFVPEHAQPE

Download         Length: 324 bp

>AT36885 NZ_AP023213:2085655-2085978 [Geobacter bremensis]
ATGGCTGACCTAAAATATCGACCGGTTGCACATGACCATAAGGCTTTCCTCAAAAAAGCAAACAAAAGAGATGGTTTCAA
AAAAGCTTACGATGAATTAGAAGAAGAATATGCCTTGGCAAAAGAGATGCTTGCTGCCCGGGCAAGAGTAGGGCTATCAC
AGGAAGCCGTCGCAGAAATTATGGGAACAACAAAGAGTGCAATCTCAAGACTGGAAGCAGTCGGTAAGCACGCCCCTTCT
TTGACTACACTCAAGAAATACGCACAGGCAGTCGGCTGCCATCTTGAGATTAAATTTGTTCCTGAGCATGCCCAACCGGA
ATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References