Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 112318..112576 Replicon plasmid pMTY18781-1_lncX3
Accession NZ_AP023206
Organism Escherichia coli strain TUM18781

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag HUV20_RS20175 Protein ID WP_000809168.1
Coordinates 112318..112470 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 112519..112576 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUV20_RS20155 107559..108272 - 714 WP_001102383.1 acidic protein MsyB -
HUV20_RS20160 108298..108702 - 405 WP_000843559.1 DUF2541 family protein -
HUV20_RS20165 109079..110995 + 1917 WP_000516135.1 molecular chaperone DnaK -
HUV20_RS20170 111084..112214 + 1131 WP_001118464.1 molecular chaperone DnaJ -
HUV20_RS20175 112318..112470 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 112519..112576 + 58 - - Antitoxin
HUV20_RS20180 113056..114222 + 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
HUV20_RS20185 114288..115187 + 900 WP_001300855.1 transcriptional activator NhaR -
HUV20_RS20190 115226..116185 - 960 WP_000871656.1 hypothetical protein -
HUV20_RS20195 116198..117550 - 1353 Protein_111 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fimA / fimI / fimC / fimD / fimF / fimG / fimH / cheD / espX1 / lpxC / lpxD / lpxA / IlpA / hcp1/tssD1 / tssA / tssA / clpV/tssH / tssL / tssJ / fha / tssG / tssF / AHA_1833 / tssB / hcp2/tssD2 / vgrG/tssI / rhs/PAAR / rhs/PAAR / rhs/PAAR / gmhA/lpcA 1..404189 404189


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T36878 WP_000809168.1 NZ_AP023206:c112470-112318 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T36878 NZ_AP023206:c112470-112318 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT36878 NZ_AP023206:112519-112576 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References