36866

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2386478..2386980 Replicon chromosome
Accession NZ_AP023205
Organism Escherichia coli strain TUM18781

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HUV20_RS11265 Protein ID WP_001570036.1
Coordinates 2386726..2386980 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HUV20_RS11260 Protein ID WP_001259255.1
Coordinates 2386478..2386729 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUV20_RS11235 2381656..2382723 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HUV20_RS11240 2382723..2383793 - 1071 WP_000108940.1 histidinol-phosphate transaminase -
HUV20_RS11245 2383790..2385094 - 1305 WP_029402287.1 histidinol dehydrogenase -
HUV20_RS11250 2385100..2385999 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
HUV20_RS11255 2386145..2386195 - 51 WP_001364200.1 his operon leader peptide -
HUV20_RS11260 2386478..2386729 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HUV20_RS11265 2386726..2386980 + 255 WP_001570036.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HUV20_RS11270 2387063..2387887 + 825 WP_000754758.1 SDR family oxidoreductase -
HUV20_RS11275 2387933..2388862 + 930 WP_089586069.1 LysR family transcriptional regulator -
HUV20_RS11280 2389077..2389139 + 63 WP_010723108.1 membrane protein YoeI -
HUV20_RS11285 2389129..2390487 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
HUV20_RS11290 2390666..2391724 + 1059 WP_023568741.1 transport protein YeeE -
HUV20_RS11295 2391738..2391965 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10199.63 Da        Isoelectric Point: 8.0353

>T36866 WP_001570036.1 NZ_AP023205:2386726-2386980 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTLFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T36866 NZ_AP023205:2386726-2386980 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCTATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT36866 WP_001259255.1 NZ_AP023205:2386478-2386729 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT36866 NZ_AP023205:2386478-2386729 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References