Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 215713..216275 Replicon chromosome
Accession NZ_AP023184
Organism Buttiauxella agrestis strain DSM 9389

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BADSM9389_RS00945 Protein ID WP_172892966.1
Coordinates 215713..215991 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BADSM9389_RS00950 Protein ID WP_172892967.1
Coordinates 215991..216275 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BADSM9389_RS00925 211289..213208 + 1920 WP_172892964.1 PTS mannitol transporter subunit IICBA -
BADSM9389_RS00930 213316..214461 + 1146 WP_172892965.1 mannitol-1-phosphate 5-dehydrogenase -
BADSM9389_RS00935 214527..215054 + 528 WP_034499385.1 MltR family transcriptional regulator -
BADSM9389_RS00940 215138..215500 + 363 WP_115626958.1 YibL family ribosome-associated protein -
BADSM9389_RS00945 215713..215991 + 279 WP_172892966.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BADSM9389_RS00950 215991..216275 + 285 WP_172892967.1 HigA family addiction module antidote protein Antitoxin
BADSM9389_RS00955 216330..217304 - 975 WP_172892968.1 glyoxylate/hydroxypyruvate reductase GhrB -
BADSM9389_RS00960 217366..218664 - 1299 WP_172892969.1 MFS transporter -
BADSM9389_RS00965 218733..219671 - 939 WP_172892970.1 sugar kinase -
BADSM9389_RS00970 219675..220424 - 750 WP_172892971.1 sugar phosphate isomerase/epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-62)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10795.39 Da        Isoelectric Point: 7.4007

>T36766 WP_172892966.1 NZ_AP023184:215713-215991 [Buttiauxella agrestis]
MIVSFKHKGLKNLFLKQQSQGLPWEHVPRLRNRLAIIDAAEKITDIDMPGYRLHALKGEREGLWSVTVSGNWRITFEFID
GDAWILNYEDYH

Download         Length: 279 bp

>T36766 NZ_AP023184:215713-215991 [Buttiauxella agrestis]
ATGATTGTAAGCTTTAAACATAAGGGACTTAAAAACCTGTTTCTAAAACAGCAGTCTCAAGGTTTGCCTTGGGAGCATGT
GCCGCGTTTACGTAACCGCCTGGCCATTATTGATGCGGCTGAAAAGATAACCGACATAGATATGCCGGGTTATCGGCTGC
ATGCACTGAAAGGTGAGCGAGAAGGTCTTTGGTCCGTTACTGTTTCCGGAAATTGGCGTATCACTTTTGAGTTTATCGAC
GGTGATGCGTGGATTCTGAATTACGAGGACTACCATTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10227.05 Da        Isoelectric Point: 7.3189

>AT36766 WP_172892967.1 NZ_AP023184:215991-216275 [Buttiauxella agrestis]
MKMKNPPHPGAIIQEALEELHVSLREFAKAMDIAPSTASRLLTEKAALTPEMAVKLAFVIGSSAEVWLKLQTAYSLAEAE
KMVDISRLHKLAAA

Download         Length: 285 bp

>AT36766 NZ_AP023184:215991-216275 [Buttiauxella agrestis]
ATGAAAATGAAAAATCCCCCGCATCCAGGGGCGATTATTCAGGAAGCGCTTGAAGAACTTCACGTGAGCTTGCGTGAGTT
TGCCAAAGCGATGGATATCGCACCTTCAACGGCGAGCCGCTTGTTAACTGAAAAAGCAGCGTTGACGCCTGAAATGGCAG
TGAAATTAGCGTTCGTTATCGGAAGCTCTGCTGAGGTATGGCTGAAATTGCAAACGGCGTACAGCCTGGCGGAAGCGGAA
AAAATGGTCGACATTTCTCGTTTGCACAAACTTGCCGCTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References