Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1946400..1947002 Replicon chromosome
Accession NZ_AP023082
Organism Francisella halioticida strain UTH170823

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag fh0823_RS10895 Protein ID WP_088773382.1
Coordinates 1946400..1946690 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag fh0823_RS10900 Protein ID WP_088773383.1
Coordinates 1946712..1947002 (+) Length 97 a.a.

Genomic Context

fh0823_RS10850fh0823_RS10855fh0823_RS10860fh0823_RS10865fh0823_RS10870fh0823_RS10875fh0823_RS10880fh0823_RS10890fh0823_RS10895fh0823_RS10900fh0823_RS10905fh0823_RS10910fh0823_RS10915fh0823_RS10920fh0823_RS10930fh0823_RS10925fh0823_RS10935
Location: 1941626..1941835 (210 bp)
Type: Others
Protein ID: WP_088773375.1
Location: 1941878..1942729 (852 bp)
Type: Others
Protein ID: WP_212789583.1
Location: 1942722..1943156 (435 bp)
Type: Others
Protein ID: WP_088773377.1
Location: 1943257..1943532 (276 bp)
Type: Others
Protein ID: WP_088773378.1
Location: 1943535..1944050 (516 bp)
Type: Others
Protein ID: WP_088773379.1
Location: 1944058..1944273 (216 bp)
Type: Others
Protein ID: WP_157671625.1
Location: 1944248..1945486 (1239 bp)
Type: Others
Protein ID: WP_212789584.1
Location: 1945659..1946324 (666 bp)
Type: Others
Protein ID: WP_088773381.1
Location: 1946400..1946690 (291 bp)
Type: Toxin
Protein ID: WP_088773382.1
Location: 1946712..1947002 (291 bp)
Type: Antitoxin
Protein ID: WP_088773383.1
Location: 1947047..1947421 (375 bp)
Type: Others
Protein ID: WP_157671626.1
Location: 1947465..1948163 (699 bp)
Type: Others
Protein ID: WP_212789585.1
Location: 1948345..1948746 (402 bp)
Type: Others
Protein ID: WP_212789586.1
Location: 1948836..1949126 (291 bp)
Type: Others
Protein ID: WP_212789587.1
Location: 1949912..1951070 (1159 bp)
Type: Others
Protein ID: WP_212788857.1
Location: 1949154..1949831 (678 bp)
Type: Others
Protein ID: WP_212789588.1
Location: 1951142..1951435 (294 bp)
Type: Others
Protein ID: WP_212788884.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
fh0823_RS10850 (fh0823_23410)1941626..1941835+210WP_088773375.1hypothetical protein-
fh0823_RS10855 (fh0823_23420)1941878..1942729+852WP_212789583.1recombination-associated protein RdgC-
fh0823_RS10860 (fh0823_23430)1942722..1943156+435WP_088773377.1DUF3568 family protein-
fh0823_RS10865 (fh0823_23440)1943257..1943532+276WP_088773378.1HU family DNA-binding protein-
fh0823_RS10870 (fh0823_23450)1943535..1944050+516WP_088773379.1single-stranded DNA-binding protein-
fh0823_RS10875 (fh0823_23460)1944058..1944273+216WP_157671625.1hypothetical protein-
fh0823_RS10880 (fh0823_23470)1944248..1945486+1239WP_212789584.1DNA polymerase IV-
fh0823_RS10890 (fh0823_23480)1945659..1946324+666WP_088773381.1DNA/RNA non-specific endonuclease-
fh0823_RS10895 (fh0823_23490)1946400..1946690+291WP_088773382.1type II toxin-antitoxin system RelE/ParE family toxinToxin
fh0823_RS10900 (fh0823_23500)1946712..1947002+291WP_088773383.1HigA family addiction module antitoxinAntitoxin
fh0823_RS10905 (fh0823_23510)1947047..1947421+375WP_157671626.1hypothetical protein-
fh0823_RS10910 (fh0823_23520)1947465..1948163+699WP_212789585.1IS6 family transposase-
fh0823_RS10915 (fh0823_23530)1948345..1948746+402WP_212789586.1hypothetical protein-
fh0823_RS10920 (fh0823_23540)1948836..1949126+291WP_212789587.1C69 family dipeptidase-
fh0823_RS10925 (fh0823_23550)1949154..1949831-678WP_212789588.1IS3 family transposase-
fh0823_RS10930 (fh0823_23570)1949912..1951070+1159WP_212788857.1IS3 family transposase-
fh0823_RS10935 (fh0823_23580)1951142..1951435-294WP_212788884.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1895796..196239766601


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11248.84 Da        Isoelectric Point: 9.8351

>T36733 WP_088773382.1 NZ_AP023082:1946400-1946690 [Francisella halioticida]
MIINFASQSANDIYNGVSSKHARKIPNTIYKTAIRKLDMVNAAKVIEDLRIPPNNRLEQLKGNLKEYHSIRINDQYRVIF
KWKDNNAYDVDIVDYH

Download         Length: 291 bp

>T36733 NZ_AP023082:1946400-1946690 [Francisella halioticida]
ATGATAATAAATTTTGCAAGTCAATCAGCCAACGATATATATAATGGTGTCTCAAGTAAGCATGCTCGTAAAATACCAAA
TACAATATATAAAACAGCTATTAGAAAACTTGATATGGTTAATGCTGCCAAAGTTATAGAAGATTTAAGAATACCTCCTA
ATAATCGTTTAGAGCAATTAAAAGGCAATTTAAAAGAATATCACTCAATTAGAATAAACGACCAATATAGAGTGATATTT
AAATGGAAAGATAACAATGCTTATGATGTTGATATAGTTGATTATCATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10796.41 Da        Isoelectric Point: 6.9875

>AT36733 WP_088773383.1 NZ_AP023082:1946712-1947002 [Francisella halioticida]
MLIPSNRKPTHPGEILLHEFIEPLSITQTKLANHLGWTYARVNEIVNGKRGITADSALSLSETFGVTPDFWLNLQMLYDL
YSAKQTHKHVAPLEVA

Download         Length: 291 bp

>AT36733 NZ_AP023082:1946712-1947002 [Francisella halioticida]
ATGCTTATACCATCAAATAGAAAACCAACACATCCAGGTGAAATATTACTACATGAATTTATTGAACCTCTATCAATAAC
ACAAACAAAATTAGCAAATCATTTAGGTTGGACTTATGCAAGAGTTAATGAGATTGTAAATGGCAAAAGAGGAATAACAG
CCGACAGTGCATTATCATTAAGTGAAACTTTTGGAGTAACACCTGACTTTTGGCTAAATTTACAAATGCTATATGATTTA
TATAGTGCGAAACAGACACACAAACATGTGGCACCATTAGAGGTAGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References