Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1946400..1947002 Replicon chromosome
Accession NZ_AP023082
Organism Francisella halioticida strain UTH170823

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag fh0823_RS10895 Protein ID WP_088773382.1
Coordinates 1946400..1946690 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag fh0823_RS10900 Protein ID WP_088773383.1
Coordinates 1946712..1947002 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
fh0823_RS10850 (fh0823_23410) 1941626..1941835 + 210 WP_088773375.1 hypothetical protein -
fh0823_RS10855 (fh0823_23420) 1941878..1942729 + 852 WP_212789583.1 recombination-associated protein RdgC -
fh0823_RS10860 (fh0823_23430) 1942722..1943156 + 435 WP_088773377.1 DUF3568 family protein -
fh0823_RS10865 (fh0823_23440) 1943257..1943532 + 276 WP_088773378.1 HU family DNA-binding protein -
fh0823_RS10870 (fh0823_23450) 1943535..1944050 + 516 WP_088773379.1 single-stranded DNA-binding protein -
fh0823_RS10875 (fh0823_23460) 1944058..1944273 + 216 WP_157671625.1 hypothetical protein -
fh0823_RS10880 (fh0823_23470) 1944248..1945486 + 1239 WP_212789584.1 DNA polymerase IV -
fh0823_RS10890 (fh0823_23480) 1945659..1946324 + 666 WP_088773381.1 DNA/RNA non-specific endonuclease -
fh0823_RS10895 (fh0823_23490) 1946400..1946690 + 291 WP_088773382.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
fh0823_RS10900 (fh0823_23500) 1946712..1947002 + 291 WP_088773383.1 HigA family addiction module antitoxin Antitoxin
fh0823_RS10905 (fh0823_23510) 1947047..1947421 + 375 WP_157671626.1 hypothetical protein -
fh0823_RS10910 (fh0823_23520) 1947465..1948163 + 699 WP_212789585.1 IS6 family transposase -
fh0823_RS10915 (fh0823_23530) 1948345..1948746 + 402 WP_212789586.1 hypothetical protein -
fh0823_RS10920 (fh0823_23540) 1948836..1949126 + 291 WP_212789587.1 C69 family dipeptidase -
fh0823_RS10925 (fh0823_23550) 1949154..1949831 - 678 WP_212789588.1 IS3 family transposase -
fh0823_RS10930 (fh0823_23570) 1949912..1951070 + 1159 WP_212788857.1 IS3 family transposase -
fh0823_RS10935 (fh0823_23580) 1951142..1951435 - 294 WP_212788884.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1895796..1962397 66601


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11248.84 Da        Isoelectric Point: 9.8351

>T36733 WP_088773382.1 NZ_AP023082:1946400-1946690 [Francisella halioticida]
MIINFASQSANDIYNGVSSKHARKIPNTIYKTAIRKLDMVNAAKVIEDLRIPPNNRLEQLKGNLKEYHSIRINDQYRVIF
KWKDNNAYDVDIVDYH

Download         Length: 291 bp

>T36733 NZ_AP023082:1946400-1946690 [Francisella halioticida]
ATGATAATAAATTTTGCAAGTCAATCAGCCAACGATATATATAATGGTGTCTCAAGTAAGCATGCTCGTAAAATACCAAA
TACAATATATAAAACAGCTATTAGAAAACTTGATATGGTTAATGCTGCCAAAGTTATAGAAGATTTAAGAATACCTCCTA
ATAATCGTTTAGAGCAATTAAAAGGCAATTTAAAAGAATATCACTCAATTAGAATAAACGACCAATATAGAGTGATATTT
AAATGGAAAGATAACAATGCTTATGATGTTGATATAGTTGATTATCATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10796.41 Da        Isoelectric Point: 6.9875

>AT36733 WP_088773383.1 NZ_AP023082:1946712-1947002 [Francisella halioticida]
MLIPSNRKPTHPGEILLHEFIEPLSITQTKLANHLGWTYARVNEIVNGKRGITADSALSLSETFGVTPDFWLNLQMLYDL
YSAKQTHKHVAPLEVA

Download         Length: 291 bp

>AT36733 NZ_AP023082:1946712-1947002 [Francisella halioticida]
ATGCTTATACCATCAAATAGAAAACCAACACATCCAGGTGAAATATTACTACATGAATTTATTGAACCTCTATCAATAAC
ACAAACAAAATTAGCAAATCATTTAGGTTGGACTTATGCAAGAGTTAATGAGATTGTAAATGGCAAAAGAGGAATAACAG
CCGACAGTGCATTATCATTAAGTGAAACTTTTGGAGTAACACCTGACTTTTGGCTAAATTTACAAATGCTATATGATTTA
TATAGTGCGAAACAGACACACAAACATGTGGCACCATTAGAGGTAGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References