Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3152800..3153365 Replicon chromosome
Accession NZ_AP023081
Organism Pseudomonas solani strain Sm006

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PSm6_RS14295 Protein ID WP_265170420.1
Coordinates 3152800..3153078 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PSm6_RS14300 Protein ID WP_265170421.1
Coordinates 3153078..3153365 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSm6_RS14275 (PSm6_28680) 3148063..3149421 + 1359 WP_265170416.1 adenylate synthase -
PSm6_RS14280 (PSm6_28690) 3149409..3150563 + 1155 WP_265170417.1 ATP-grasp domain-containing protein -
PSm6_RS14285 (PSm6_28700) 3150560..3151699 + 1140 WP_265170418.1 hypothetical protein -
PSm6_RS14290 (PSm6_28710) 3151696..3152697 + 1002 WP_265170419.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
PSm6_RS14295 (PSm6_28720) 3152800..3153078 + 279 WP_265170420.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PSm6_RS14300 (PSm6_28730) 3153078..3153365 + 288 WP_265170421.1 HigA family addiction module antitoxin Antitoxin
PSm6_RS14305 (PSm6_28740) 3153442..3153969 - 528 WP_021216753.1 inorganic diphosphatase -
PSm6_RS14310 (PSm6_28750) 3154048..3154866 - 819 WP_021216752.1 zinc-dependent peptidase -
PSm6_RS14315 (PSm6_28760) 3154871..3155536 - 666 WP_021216751.1 DedA family protein -
PSm6_RS14320 (PSm6_28770) 3155780..3156238 - 459 WP_021216750.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10601.17 Da        Isoelectric Point: 9.9894

>T36730 WP_265170420.1 NZ_AP023081:3152800-3153078 [Pseudomonas solani]
MIKSFQHKGLRKLFETGSTAGVQAVHAKRLRMQLAALNTAMTIDDMDVPGFRLHPLKGEMRGRWSITVSGNWRLTFEFRD
GNAYVLDYEDYH

Download         Length: 279 bp

>T36730 NZ_AP023081:3152800-3153078 [Pseudomonas solani]
ATGATCAAGTCTTTCCAGCACAAGGGGCTGCGCAAGCTCTTCGAAACGGGCAGCACGGCAGGTGTACAGGCCGTTCATGC
CAAGCGGCTGCGGATGCAACTGGCGGCTTTGAATACGGCGATGACAATTGACGATATGGACGTTCCAGGCTTTCGCCTGC
ACCCACTCAAGGGCGAAATGCGCGGGCGCTGGTCGATCACGGTGAGTGGCAATTGGCGGCTGACCTTCGAGTTTCGCGAC
GGCAACGCCTATGTCCTGGATTATGAGGATTACCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10383.96 Da        Isoelectric Point: 7.3178

>AT36730 WP_265170421.1 NZ_AP023081:3153078-3153365 [Pseudomonas solani]
MSMHNPPHPGEFITGVYLEPNGFSGRELAEKLGVAPSTLSRVLKGSSRVTPEMALRLSVALGRSPESWLAMQDAYDLWIA
RQHVDLQQVGKLAIA

Download         Length: 288 bp

>AT36730 NZ_AP023081:3153078-3153365 [Pseudomonas solani]
ATGAGCATGCACAACCCACCCCATCCCGGTGAGTTCATTACCGGTGTCTATCTGGAGCCGAACGGCTTCAGCGGTCGTGA
ATTGGCAGAAAAGCTAGGTGTTGCGCCCTCGACCCTGAGCCGTGTCCTGAAGGGTTCCAGCCGTGTCACGCCCGAGATGG
CGCTGCGCTTGTCGGTCGCGCTGGGTCGTTCGCCGGAAAGCTGGCTGGCCATGCAGGATGCCTACGATCTCTGGATCGCT
CGCCAGCATGTGGATCTGCAACAGGTAGGAAAGCTCGCCATCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References