Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 194686..195290 Replicon chromosome
Accession NZ_AP023081
Organism Pseudomonas solani strain Sm006

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PSm6_RS00910 Protein ID WP_265170484.1
Coordinates 194976..195290 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PSm6_RS00905 Protein ID WP_043243334.1
Coordinates 194686..194973 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSm6_RS00885 (PSm6_01720) 189738..190445 + 708 WP_021220501.1 winged helix-turn-helix domain-containing protein -
PSm6_RS00890 (PSm6_01730) 190449..191735 + 1287 WP_265169283.1 ATP-binding protein -
PSm6_RS00895 (PSm6_01740) 191837..193630 + 1794 WP_265169284.1 serine hydrolase domain-containing protein -
PSm6_RS00900 (PSm6_01750) 193655..194437 + 783 WP_265169285.1 MipA/OmpV family protein -
PSm6_RS00905 (PSm6_01760) 194686..194973 - 288 WP_043243334.1 NadS family protein Antitoxin
PSm6_RS00910 (PSm6_01770) 194976..195290 - 315 WP_265170484.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PSm6_RS00930 (PSm6_01780) 196042..196896 + 855 WP_184488001.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD -
PSm6_RS00935 (PSm6_01790) 196989..198725 - 1737 WP_265169286.1 ABC transporter substrate-binding protein -
PSm6_RS00940 (PSm6_01800) 198759..199031 - 273 WP_021220495.1 DUF2160 domain-containing protein -
PSm6_RS00945 (PSm6_01810) 199040..199840 - 801 WP_043243335.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11950.71 Da        Isoelectric Point: 9.8598

>T36726 WP_265170484.1 NZ_AP023081:c195290-194976 [Pseudomonas solani]
MIFIETPLFTRRLRELLDDDSYAAFQRLLAERPEMGDVIEGTGGIRKVRVASGGHGKRGGSRVIYYHFSSASQIALLLIY
PKNEKDDLTADERKALRQIIERWR

Download         Length: 315 bp

>T36726 NZ_AP023081:c195290-194976 [Pseudomonas solani]
ATGATCTTCATCGAGACACCCCTCTTCACCCGGCGTCTTCGCGAGTTGCTCGACGATGACAGTTACGCGGCCTTCCAGCG
GTTGCTGGCCGAGCGGCCGGAAATGGGGGATGTGATCGAGGGCACGGGTGGCATCCGCAAGGTGCGGGTGGCCAGTGGCG
GTCATGGCAAGCGCGGCGGGTCGAGGGTCATCTATTACCATTTCTCGTCCGCCTCGCAGATCGCCTTGCTGCTGATCTAC
CCCAAGAACGAGAAGGATGACCTGACCGCGGATGAGCGCAAGGCGCTCAGGCAGATCATCGAGCGCTGGAGGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10716.28 Da        Isoelectric Point: 10.2879

>AT36726 WP_043243334.1 NZ_AP023081:c194973-194686 [Pseudomonas solani]
MSQFFDDLMESVQQMDEIRRGERKPSREFTVDALQVKAIRKATGLTQARFAAMIDVQLGTLRNWEQGRREPTGPAKALLR
AIHNDPVHVIQALGG

Download         Length: 288 bp

>AT36726 NZ_AP023081:c194973-194686 [Pseudomonas solani]
ATGAGCCAATTCTTCGACGACCTGATGGAAAGCGTCCAGCAGATGGACGAGATACGCCGTGGCGAGCGCAAGCCTTCGCG
TGAGTTCACCGTGGATGCGCTGCAGGTGAAGGCGATCCGCAAGGCAACGGGCCTGACACAGGCTAGGTTCGCCGCGATGA
TCGATGTTCAGCTGGGTACCCTGCGCAATTGGGAGCAGGGGCGACGTGAGCCCACCGGCCCCGCCAAGGCGCTGCTGCGC
GCCATCCACAATGACCCCGTGCACGTTATCCAGGCCCTTGGGGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References