Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5556..6214 Replicon plasmid pOCU_Ac16a_1
Accession NZ_AP023078
Organism Acinetobacter baumannii strain OCU_Ac16a

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OCUAC_RS19150 Protein ID WP_000312250.1
Coordinates 5855..6214 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OCUAC_RS19145 Protein ID WP_001096429.1
Coordinates 5556..5855 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCUAC_RS19115 970..2226 + 1257 WP_072689898.1 ParB/RepB/Spo0J family partition protein -
OCUAC_RS19120 2362..3591 + 1230 WP_033854393.1 hypothetical protein -
OCUAC_RS19125 3606..3839 + 234 WP_033854394.1 hypothetical protein -
OCUAC_RS19130 3880..4137 + 258 WP_000834290.1 hypothetical protein -
OCUAC_RS19135 4142..4714 + 573 WP_000443897.1 hypothetical protein -
OCUAC_RS19140 4690..4869 + 180 WP_033854395.1 hypothetical protein -
OCUAC_RS19145 5556..5855 - 300 WP_001096429.1 helix-turn-helix transcriptional regulator Antitoxin
OCUAC_RS19150 5855..6214 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCUAC_RS19155 6415..6981 + 567 WP_000710385.1 hypothetical protein -
OCUAC_RS19160 7188..8537 - 1350 WP_072689902.1 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..73028 73028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T36723 WP_000312250.1 NZ_AP023078:c6214-5855 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T36723 NZ_AP023078:c6214-5855 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT36723 WP_001096429.1 NZ_AP023078:c5855-5556 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT36723 NZ_AP023078:c5855-5556 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References