Detailed information of TA system TA036722

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 3654982..3655567
• Replicon: chromosome
• Accession: NZ_AP023077
• Organism: Acinetobacter baumannii strain OCU_Ac16a

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A7S7BY50
• Locus tag: OCUAC_RS17505
• Protein ID: WP_000897311.1
• Coordinates: 3654982..3655302 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: OCUAC_RS17510
• Protein ID: WP_000369784.1
• Coordinates: 3655295..3655567 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCUAC_RS17480	3650323..3650580	-	258	Protein_3409	WYL domain-containing protein	-
OCUAC_RS17485	3650789..3651118	+	330	WP_000506885.1	DUF4236 domain-containing protein	-
OCUAC_RS17490	3651390..3652622	-	1233	WP_001255534.1	ATP-binding protein	-
OCUAC_RS17495	3652880..3653317	-	438	Protein_3412	IS3 family transposase	-
OCUAC_RS17500	3653371..3654303	+	933	WP_000743272.1	IS5-like element IS17 family transposase	-
OCUAC_RS17505	3654982..3655302	+	321	WP_000897311.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCUAC_RS17510	3655295..3655567	+	273	WP_000369784.1	helix-turn-helix domain-containing protein	Antitoxin
OCUAC_RS17515	3655600..3656370	+	771	WP_072690102.1	DUF2971 domain-containing protein	-
OCUAC_RS17520	3656417..3657121	+	705	WP_001067790.1	IS6-like element IS1008 family transposase	-
OCUAC_RS17525	3657174..3658445	+	1272	Protein_3418	hypothetical protein	-
OCUAC_RS17530	3658527..3659471	+	945	WP_000851073.1	hypothetical protein	-
OCUAC_RS17535	3659493..3660350	+	858	WP_000765385.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3645842..3656370	10528
	-	inside	IScluster/Tn	-	-	3649205..3657121	7916

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-84)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12214.03 Da
• Isoelectric Point: 7.9500

>T36722 WP_000897311.1 NZ_AP023077:3654982-3655302 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVTDEEYRQLQQDLLIQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFNG

Nucleotide

• Length: 321 bp

>T36722 NZ_AP023077:3654982-3655302 [Acinetobacter baumannii]
ATGTTATTCATTGAAACCAGTATTTTTACCAAGCAAATCAAAGAGCTTGTTACTGATGAAGAATATCGTCAACTCCAGCA
AGATCTATTGATACAACCTGATAAAGGAGACTTGATCAAAAATGGTGGTGGCATTCGTAAAGTCCGTTGTGCTCAGGGTA
ATAAAGGCAAAAGTGGCGGTATTCGTGTGATCTATTACTGGGTTACAGAGGATGATCAGATTTTTTTCCTAGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAGACCTCGATCCTGCGTCAATTAGTGAAGGAGCAATTTAATGGATA
A

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10145.57 Da
• Isoelectric Point: 7.0146

>AT36722 WP_000369784.1 NZ_AP023077:3655295-3655567 [Acinetobacter baumannii]
MDNNLFDDLVTSIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDTNPTLI

Nucleotide

• Length: 273 bp

>AT36722 NZ_AP023077:3655295-3655567 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACCTCGTTACTTCCATCAAAGAAGCTGGAGCCATCAAACGTAATGAGATAAAGGCAAG
TCGAGTAACAGAACTTGAATTGCCTGATATTAAAGAAGTACGTGAGAAAACAGGCTTAACCCAGGCAGAGTTTGCTGCAC
GCTTACATATTAGCGCGAGAACTCTACAAAATTGGGAACAAGGTCGTCGCTATCCGACTGGCCCAGCAGCGACTTTGATT
CGTATTCTTGATACCAATCCAACTCTGATTTAG

Structures

Toxin

• AlphaFold DB: A0A7S7BY50