Detailed information of TA system TA036719

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 3643885..3644470
• Replicon: chromosome
• Accession: NZ_AP023077
• Organism: Acinetobacter baumannii strain OCU_Ac16a

Toxin (Protein)

• Gene name: higB
• Uniprot ID: N9CJF7
• Locus tag: OCUAC_RS17425
• Protein ID: WP_000897307.1
• Coordinates: 3644150..3644470 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: OCUAC_RS17420
• Protein ID: WP_000369781.1
• Coordinates: 3643885..3644157 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCUAC_RS17400	3638958..3639920	-	963	WP_033917576.1	IS30 family transposase	-
OCUAC_RS17405	3640176..3640787	+	612	WP_015060246.1	recombinase family protein	-
OCUAC_RS17410	3640977..3641861	-	885	WP_000155092.1	Mph(E) family macrolide 2'-phosphotransferase	-
OCUAC_RS17415	3641917..3643392	-	1476	WP_000052512.1	ABC-F type ribosomal protection protein Msr(E)	-
OCUAC_RS17420	3643885..3644157	-	273	WP_000369781.1	helix-turn-helix domain-containing protein	Antitoxin
OCUAC_RS17425	3644150..3644470	-	321	WP_000897307.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCUAC_RS17430	3644610..3645029	+	420	WP_001180106.1	SMI1/KNR4 family protein	-
OCUAC_RS17435	3645109..3645390	-	282	WP_000985609.1	putative addiction module antidote protein	-
OCUAC_RS17440	3645391..3645693	-	303	WP_000286964.1	type II toxin-antitoxin system RelE/ParE family toxin	-
OCUAC_RS17445	3645842..3646372	+	531	WP_000172759.1	hypothetical protein	-
OCUAC_RS17450	3646461..3646775	-	315	WP_004728120.1	BrnA antitoxin family protein	-
OCUAC_RS17455	3646762..3647049	-	288	WP_000438825.1	BrnT family toxin	-
OCUAC_RS17460	3647279..3647884	-	606	WP_000447788.1	LysE family translocator	-
OCUAC_RS17465	3647934..3648762	-	829	Protein_3406	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12187.95 Da
• Isoelectric Point: 7.1639

>T36719 WP_000897307.1 NZ_AP023077:c3644470-3644150 [Acinetobacter baumannii]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG

Nucleotide

• Length: 321 bp

>T36719 NZ_AP023077:c3644470-3644150 [Acinetobacter baumannii]
ATGTTATTTATTGAAACCAGCATCTTTACCAAGCAAATTAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAGCA
AGATCTTTTGGTACAGCCTGATAGAGGTGACCTAATCAAGAATGGCGGTGGTATTCGCAAAGTACGTTGTGCTCAAGGTA
ACAAAGGGAAAAGTGGTGGGATACGGGTGATTTATTATTGGGTCACCGAGGATGATCAGATCTTTTTCTTAGTGGCTTAT
CCAAAATCAGTAAAAGATAATTTAACAGATAAGGAAACCGCCATTCTGCACCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10149.61 Da
• Isoelectric Point: 8.6582

>AT36719 WP_000369781.1 NZ_AP023077:c3644157-3643885 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Nucleotide

• Length: 273 bp

>AT36719 NZ_AP023077:c3644157-3643885 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATCAAAGAAGCTGGAGCTATCAAACGTAAAGAAGTTAAAGCAAG
CCGAGTTACAGAACTCGAATTGCCTGATATTAAAGAAGTACGTGAAAAAACTGGCTTGAGCCAAAATGAATTTGCTGCAC
GTCTACATATTAGCCCCCGTACCCTGCAAAATTGGGAACAGGGACGACGCTATCCAACTGGACCAGCAGCTACATTGATT
CGAATTTTAGATGCTCACCCAAGCCTTATTTGA

Structures

Toxin

• AlphaFold DB: A0A0A8TMZ3