Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2535929..2536113 Replicon chromosome
Accession NZ_AP023034
Organism Staphylococcus aureus strain TPS3156

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag HZ307_RS12760 Protein ID WP_000482650.1
Coordinates 2536006..2536113 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2535929..2535989 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ307_RS12745 2531459..2531626 - 168 WP_001790576.1 hypothetical protein -
HZ307_RS12750 2531857..2533590 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
HZ307_RS12755 2533615..2535378 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2535929..2535989 + 61 - - Antitoxin
HZ307_RS12760 2536006..2536113 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
HZ307_RS12765 2536247..2536633 - 387 WP_000779358.1 flippase GtxA -
HZ307_RS12770 2536901..2538043 + 1143 WP_001176863.1 glycerate kinase -
HZ307_RS12775 2538103..2538762 + 660 WP_000831298.1 membrane protein -
HZ307_RS12780 2538944..2540155 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
HZ307_RS12785 2540278..2540751 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T36683 WP_000482650.1 NZ_AP023034:c2536113-2536006 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T36683 NZ_AP023034:c2536113-2536006 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT36683 NZ_AP023034:2535929-2535989 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References