Detailed information of TA system TA036674

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2057863..2058162
• Replicon: chromosome
• Accession: NZ_AP023034
• Organism: Staphylococcus aureus strain TPS3156

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: HZ307_RS10170
• Protein ID: WP_011447039.1
• Coordinates: 2057986..2058162 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2057863..2057918 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZ307_RS10130	2053194..2053454	+	261	WP_001791826.1	hypothetical protein	-
HZ307_RS10135	2053507..2053857	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
HZ307_RS10140	2054542..2054991	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
HZ307_RS10145	2055086..2055421	-	336	Protein_1959	SH3 domain-containing protein	-
HZ307_RS10150	2056071..2056562	-	492	WP_000919350.1	staphylokinase	-
HZ307_RS10155	2056753..2057508	-	756	WP_000861038.1	CHAP domain-containing protein	-
HZ307_RS10160	2057520..2057774	-	255	WP_000611512.1	phage holin	-
HZ307_RS10165	2057826..2057933	+	108	WP_001791821.1	hypothetical protein	-
-	2057855..2057994	+	140	NuclAT_0	-	-
-	2057855..2057994	+	140	NuclAT_0	-	-
-	2057855..2057994	+	140	NuclAT_0	-	-
-	2057855..2057994	+	140	NuclAT_0	-	-
-	2057863..2057918	+	56	-	-	Antitoxin
HZ307_RS10170	2057986..2058162	-	177	WP_011447039.1	putative holin-like toxin	Toxin
HZ307_RS10175	2058312..2058608	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
HZ307_RS10180	2058666..2058953	-	288	WP_178890282.1	hypothetical protein	-
HZ307_RS10185	2059000..2059152	-	153	WP_001153681.1	hypothetical protein	-
HZ307_RS10190	2059142..2062927	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2053507..2109455	55948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T36674 WP_011447039.1 NZ_AP023034:c2058162-2057986 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T36674 NZ_AP023034:c2058162-2057986 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT36674 NZ_AP023034:2057863-2057918 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin