Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4514422..4515110 Replicon chromosome
Accession NZ_AP022871
Organism Phytohabitans suffuscus strain NBRC 105367

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag Psuf_RS19775 Protein ID WP_173158554.1
Coordinates 4514422..4514787 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Psuf_RS19780 Protein ID WP_173158555.1
Coordinates 4514784..4515110 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psuf_RS19755 4510183..4510955 - 773 Protein_3953 MBL fold metallo-hydrolase -
Psuf_RS19760 4511024..4512238 + 1215 WP_173158552.1 NADP-dependent isocitrate dehydrogenase -
Psuf_RS19765 4512572..4513342 + 771 WP_173158553.1 DeoR/GlpR family DNA-binding transcription regulator -
Psuf_RS19770 4513339..4514384 + 1046 Protein_3956 galactose-1-phosphate uridylyltransferase -
Psuf_RS19775 4514422..4514787 + 366 WP_173158554.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Psuf_RS19780 4514784..4515110 + 327 WP_173158555.1 helix-turn-helix transcriptional regulator Antitoxin
Psuf_RS19785 4515206..4516036 + 831 WP_173158556.1 alpha/beta fold hydrolase -
Psuf_RS19790 4516033..4517262 + 1230 WP_173158557.1 Type 1 glutamine amidotransferase-like domain-containing protein -
Psuf_RS19795 4517900..4518767 - 868 Protein_3961 redoxin domain-containing protein -
Psuf_RS19800 4518788..4519006 - 219 WP_173158558.1 hypothetical protein -
Psuf_RS19805 4518955..4519521 - 567 WP_173158559.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(41-97)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13573.48 Da        Isoelectric Point: 5.6205

>T36627 WP_173158554.1 NZ_AP022871:4514422-4514787 [Phytohabitans suffuscus]
VWEIRLHPEVESWFLDLCRTDSASADLVAEAIDLLAEFGPALGRPLVDRLKSSRYHHMKELRPGSAGASEMRLIFAFDPA
REAIFLAAGDKAGRWQSWYKTAIPLADARLAEHLASLKEEQ

Download         Length: 366 bp

>T36627 NZ_AP022871:4514422-4514787 [Phytohabitans suffuscus]
GTGTGGGAGATCCGGCTCCACCCGGAGGTCGAGTCTTGGTTCCTCGATCTTTGTCGTACGGATTCGGCGAGCGCGGATCT
CGTCGCCGAGGCGATTGACCTCCTCGCGGAGTTCGGTCCCGCACTCGGTCGTCCATTGGTCGATCGCCTCAAGAGCAGCA
GGTATCACCACATGAAGGAGCTGCGGCCGGGGTCCGCTGGAGCGAGCGAGATGCGTCTGATCTTTGCGTTCGATCCGGCG
CGGGAGGCGATCTTCCTTGCGGCGGGAGACAAGGCCGGGCGTTGGCAGAGTTGGTACAAGACAGCGATTCCACTGGCAGA
CGCCCGCCTCGCGGAGCACCTGGCATCGCTGAAGGAGGAGCAATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11710.24 Da        Isoelectric Point: 7.2045

>AT36627 WP_173158555.1 NZ_AP022871:4514784-4515110 [Phytohabitans suffuscus]
MSTNWRDVTAKARANDPEWDSAERVDRRAKMRQEMLASVSGAQLAEIRKQLGLTQAQLAEATGLSQARVSQIENGGVTSL
ETLRVYVAGLGGHLEIIAHIGNIQLNVA

Download         Length: 327 bp

>AT36627 NZ_AP022871:4514784-4515110 [Phytohabitans suffuscus]
ATGAGCACCAACTGGCGCGATGTCACGGCCAAGGCGCGGGCGAACGATCCAGAGTGGGACAGCGCCGAACGTGTCGACCG
GCGCGCCAAGATGCGCCAAGAGATGCTCGCCTCCGTGAGCGGGGCTCAACTCGCCGAAATCCGCAAGCAACTCGGTCTGA
CCCAGGCGCAGCTCGCTGAGGCCACCGGCCTGTCGCAGGCCCGCGTCAGCCAGATCGAAAACGGCGGCGTCACAAGCCTG
GAGACCTTGCGGGTGTACGTGGCCGGGTTGGGCGGCCACCTGGAAATCATCGCCCACATCGGCAACATCCAGCTGAACGT
GGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References