Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 9215875..9216619 Replicon chromosome
Accession NZ_AP022870
Organism Phytohabitans flavus strain NBRC 107702

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag Pflav_RS41060 Protein ID WP_173041880.1
Coordinates 9216206..9216619 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Pflav_RS41055 Protein ID WP_173041879.1
Coordinates 9215875..9216213 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Pflav_RS41035 9212155..9212447 + 293 Protein_8214 DUF503 domain-containing protein -
Pflav_RS41040 9212542..9213018 + 477 WP_173041878.1 30S ribosome-binding factor RbfA -
Pflav_RS41045 9213024..9214076 + 1053 WP_173042929.1 bifunctional oligoribonuclease/PAP phosphatase NrnA -
Pflav_RS41050 9214578..9215878 + 1301 Protein_8217 MATE family efflux transporter -
Pflav_RS41055 9215875..9216213 - 339 WP_173041879.1 XRE family transcriptional regulator Antitoxin
Pflav_RS41060 9216206..9216619 - 414 WP_173041880.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Pflav_RS41065 9216728..9217609 + 882 WP_173041881.1 tRNA pseudouridine(55) synthase TruB -
Pflav_RS41070 9217599..9220592 - 2994 WP_173041882.1 NACHT domain-containing protein -
Pflav_RS41075 9220689..9221615 + 927 WP_173041883.1 bifunctional riboflavin kinase/FAD synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(31-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15277.78 Da        Isoelectric Point: 11.1657

>T36621 WP_173041880.1 NZ_AP022870:c9216619-9216206 [Phytohabitans flavus]
MLPALYLSPWSRTVRWSIIVLEPARSWLHSLRRTDRATLVLVSQAIEALSIEGPGLGRPLVDTVKGSRLANLKELRPGSS
GAAKVRVLFVFDPLRQAVILVGGDKAGRWRGWYRSAIPMAEAAFAEHLKRVEEQTHE

Download         Length: 414 bp

>T36621 NZ_AP022870:c9216619-9216206 [Phytohabitans flavus]
ATGTTGCCAGCATTATACTTGTCCCCGTGGAGCCGCACCGTGAGGTGGTCAATCATCGTCCTGGAGCCGGCCCGTTCCTG
GCTCCATTCGCTACGCCGCACCGACCGCGCCACGTTGGTGCTGGTCAGCCAGGCCATCGAGGCGCTGAGCATCGAGGGCC
CCGGCCTCGGCCGGCCGCTGGTCGACACGGTCAAGGGCTCCCGCCTGGCAAATCTCAAGGAGCTGCGACCGGGTTCGAGC
GGTGCCGCGAAGGTTCGGGTCCTGTTCGTCTTCGACCCACTCCGGCAAGCGGTGATCCTCGTCGGCGGCGACAAAGCCGG
CCGCTGGCGGGGGTGGTACAGGTCGGCGATTCCCATGGCCGAGGCGGCATTTGCCGAGCATCTGAAACGCGTGGAGGAGC
AGACGCATGAGTGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12497.97 Da        Isoelectric Point: 5.0052

>AT36621 WP_173041879.1 NZ_AP022870:c9216213-9215875 [Phytohabitans flavus]
MSEHLSDPDARSWEDLKDELAFTEAEQAEIDAGARRFVAEARAHRLAEVRRRQHTTQVEVAKAMGVTQARVSRIEKGQLA
RTEVETLAAYVRALGGKLTIVAEFDDESYVLG

Download         Length: 339 bp

>AT36621 NZ_AP022870:c9216213-9215875 [Phytohabitans flavus]
ATGAGTGAGCACCTGAGCGACCCGGATGCCCGCTCCTGGGAGGACCTCAAAGACGAGCTGGCCTTCACGGAGGCGGAGCA
GGCCGAGATCGACGCCGGTGCGCGCCGGTTCGTCGCCGAGGCGCGGGCGCACCGGCTCGCGGAGGTGCGGCGCCGCCAGC
ACACGACCCAGGTCGAGGTGGCCAAGGCGATGGGCGTCACCCAGGCCCGCGTCTCCCGGATCGAAAAGGGCCAGCTCGCG
CGGACCGAGGTGGAGACGCTCGCCGCTTACGTGCGGGCTCTCGGCGGCAAGCTCACGATCGTGGCCGAGTTCGACGACGA
GTCGTATGTGCTGGGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References