Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3694413..3694984 Replicon chromosome
Accession NZ_AP022869
Organism Halomonas meridiana strain Eplume2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HMEPL2_RS17480 Protein ID WP_172515562.1
Coordinates 3694413..3694691 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HMEPL2_RS17485 Protein ID WP_172515563.1
Coordinates 3694691..3694984 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMEPL2_RS17460 3689866..3691701 - 1836 WP_172515742.1 phosphomethylpyrimidine synthase ThiC -
HMEPL2_RS17465 3691810..3692478 - 669 WP_172515561.1 thiaminase II -
HMEPL2_RS17470 3692788..3693755 - 968 Protein_3425 integron integrase -
HMEPL2_RS17475 3694017..3694301 + 285 WP_081193111.1 hypothetical protein -
HMEPL2_RS17480 3694413..3694691 + 279 WP_172515562.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HMEPL2_RS17485 3694691..3694984 + 294 WP_172515563.1 HigA family addiction module antidote protein Antitoxin
HMEPL2_RS17490 3695080..3695553 + 474 WP_172515564.1 hypothetical protein -
HMEPL2_RS17495 3695566..3695760 + 195 WP_172515565.1 DUF1737 domain-containing protein -
HMEPL2_RS17500 3695763..3696053 + 291 WP_172515566.1 DUF1737 domain-containing protein -
HMEPL2_RS17505 3696700..3696701 - 2 WP_172515567.1 IS630 family transposase -
HMEPL2_RS17510 3697243..3697707 + 465 WP_197746091.1 hypothetical protein -
HMEPL2_RS17515 3697926..3699287 - 1362 WP_172515568.1 IS1380 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3686410..3711999 25589
- inside Integron - - 3692964..3697707 4743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10737.17 Da        Isoelectric Point: 10.0575

>T36617 WP_172515562.1 NZ_AP022869:3694413-3694691 [Halomonas meridiana]
MIKSFRHKGLKRFYSTGSTSGIQPDHAKKLRMQLTALDTATSVDDMDIPGFRLHPLKGRDKGRWSIRVNGNWRMTFEFQD
GNAYILDYEDYH

Download         Length: 279 bp

>T36617 NZ_AP022869:3694413-3694691 [Halomonas meridiana]
ATGATTAAATCATTCCGTCACAAAGGACTGAAGCGGTTCTACTCGACCGGCAGCACGTCTGGCATACAGCCGGATCATGC
TAAGAAACTGCGCATGCAGCTGACAGCTCTGGATACCGCCACTTCGGTGGATGATATGGATATCCCTGGTTTTCGGCTTC
ACCCATTGAAGGGGCGAGACAAAGGGCGGTGGTCGATTCGTGTTAACGGAAATTGGCGCATGACGTTCGAATTTCAGGAC
GGCAACGCCTACATTCTTGATTATGAGGATTATCACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10777.32 Da        Isoelectric Point: 6.0610

>AT36617 WP_172515563.1 NZ_AP022869:3694691-3694984 [Halomonas meridiana]
MTMHNPPHPGEFIREVYLEPFGISSRQLASSLGVSPSTLSRLLKGDSGISPEMSLRLSKVLGRSPESWLAMQDMYDLWVA
RHTVNLDGIHPLDFEAA

Download         Length: 294 bp

>AT36617 NZ_AP022869:3694691-3694984 [Halomonas meridiana]
ATGACTATGCATAATCCGCCGCATCCTGGTGAATTCATTCGGGAGGTGTACCTGGAGCCTTTCGGTATCAGTTCCCGTCA
GCTTGCTTCCAGTCTGGGGGTCTCTCCCTCCACTTTGTCTCGACTGCTCAAAGGGGATAGTGGTATTAGCCCGGAAATGT
CGCTTCGGCTATCCAAGGTTCTCGGACGTTCTCCTGAGAGTTGGTTGGCGATGCAAGATATGTACGATCTATGGGTGGCC
CGCCACACGGTCAACCTGGATGGAATCCATCCCCTGGACTTCGAGGCAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References