Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 3393060..3393604 | Replicon | chromosome |
| Accession | NZ_AP022869 | ||
| Organism | Halomonas meridiana strain Eplume2 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | HMEPL2_RS16070 | Protein ID | WP_172515450.1 |
| Coordinates | 3393060..3393275 (+) | Length | 72 a.a. |
Antitoxin (Protein)
| Gene name | graA | Uniprot ID | G6YV52 |
| Locus tag | HMEPL2_RS16075 | Protein ID | WP_008174257.1 |
| Coordinates | 3393290..3393604 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HMEPL2_RS16040 | 3388522..3389388 | + | 867 | WP_172515446.1 | hypothetical protein | - |
| HMEPL2_RS16045 | 3389637..3389942 | + | 306 | WP_172515447.1 | hypothetical protein | - |
| HMEPL2_RS16050 | 3390028..3390573 | + | 546 | WP_172515448.1 | GNAT family N-acetyltransferase | - |
| HMEPL2_RS16055 | 3390690..3390968 | + | 279 | WP_008174254.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HMEPL2_RS16060 | 3390979..3391266 | + | 288 | WP_036148342.1 | HigA family addiction module antidote protein | - |
| HMEPL2_RS16065 | 3391660..3393015 | - | 1356 | WP_172515449.1 | IS1182 family transposase | - |
| HMEPL2_RS16070 | 3393060..3393275 | + | 216 | WP_172515450.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HMEPL2_RS16075 | 3393290..3393604 | + | 315 | WP_008174257.1 | HigA family addiction module antidote protein | Antitoxin |
| HMEPL2_RS16080 | 3393679..3393951 | - | 273 | WP_054641814.1 | BrnA antitoxin family protein | - |
| HMEPL2_RS16085 | 3393926..3394237 | - | 312 | WP_054641813.1 | BrnT family toxin | - |
| HMEPL2_RS16090 | 3394342..3394671 | + | 330 | WP_197746083.1 | hypothetical protein | - |
| HMEPL2_RS16095 | 3394850..3395107 | + | 258 | WP_022992576.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HMEPL2_RS16100 | 3395095..3395397 | + | 303 | WP_054641811.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HMEPL2_RS16105 | 3395534..3395803 | + | 270 | WP_022990375.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HMEPL2_RS16110 | 3395804..3396103 | + | 300 | WP_062373125.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HMEPL2_RS16115 | 3396015..3396230 | + | 216 | WP_084812740.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| HMEPL2_RS16120 | 3396300..3396617 | - | 318 | WP_062373121.1 | CcdB family protein | - |
| HMEPL2_RS16125 | 3396617..3396862 | - | 246 | WP_172515451.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| HMEPL2_RS16130 | 3396986..3397333 | + | 348 | Protein_3160 | MBL fold metallo-hydrolase | - |
| HMEPL2_RS16135 | 3397362..3398015 | + | 654 | WP_062373116.1 | DsbA family oxidoreductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3387248..3403389 | 16141 | |
| - | flank | IS/Tn | - | - | 3391660..3393015 | 1355 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 72 a.a. Molecular weight: 8250.24 Da Isoelectric Point: 6.7068
>T36614 WP_172515450.1 NZ_AP022869:3393060-3393275 [Halomonas meridiana]
VQRKDRQAARKLEYVDLAVQLEDLKVPPGNRLHPLSGNRQGQHAISINDQWRICFRFEGGDAYEVEVCDYH
VQRKDRQAARKLEYVDLAVQLEDLKVPPGNRLHPLSGNRQGQHAISINDQWRICFRFEGGDAYEVEVCDYH
Download Length: 216 bp
>T36614 NZ_AP022869:3393060-3393275 [Halomonas meridiana]
GTGCAACGGAAAGACCGACAGGCTGCTAGAAAACTTGAATACGTGGATCTGGCCGTACAGCTTGAGGATTTGAAAGTGCC
GCCCGGCAATCGCCTTCACCCACTGTCGGGAAACAGGCAGGGGCAGCACGCAATTTCAATCAATGATCAGTGGCGTATCT
GTTTTCGTTTTGAAGGTGGCGATGCGTATGAAGTCGAAGTGTGTGACTACCACTGA
GTGCAACGGAAAGACCGACAGGCTGCTAGAAAACTTGAATACGTGGATCTGGCCGTACAGCTTGAGGATTTGAAAGTGCC
GCCCGGCAATCGCCTTCACCCACTGTCGGGAAACAGGCAGGGGCAGCACGCAATTTCAATCAATGATCAGTGGCGTATCT
GTTTTCGTTTTGAAGGTGGCGATGCGTATGAAGTCGAAGTGTGTGACTACCACTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11644.33 Da Isoelectric Point: 7.2052
>AT36614 WP_008174257.1 NZ_AP022869:3393290-3393604 [Halomonas meridiana]
MAILNTAGMQRKPTHPGEMLREDFLPDYGLTVSGLAESLGVSRQSVNELLRERRAVSPEMALRLARLFGNSPEFWLNAQR
SVDLWTAAQSVKEEVDRIKPLHAA
MAILNTAGMQRKPTHPGEMLREDFLPDYGLTVSGLAESLGVSRQSVNELLRERRAVSPEMALRLARLFGNSPEFWLNAQR
SVDLWTAAQSVKEEVDRIKPLHAA
Download Length: 315 bp
>AT36614 NZ_AP022869:3393290-3393604 [Halomonas meridiana]
ATGGCTATTCTTAATACTGCTGGCATGCAGCGCAAACCGACTCATCCTGGCGAAATGCTGAGGGAAGACTTTCTTCCGGA
CTATGGTCTGACGGTTTCGGGGTTGGCCGAATCTTTGGGTGTCTCTCGTCAGTCAGTGAATGAACTATTGCGGGAACGCC
GTGCTGTCAGCCCTGAAATGGCGCTCAGGCTTGCGCGTTTGTTTGGTAACTCGCCAGAATTCTGGCTGAACGCACAGCGG
TCTGTTGATCTTTGGACTGCTGCGCAGTCGGTCAAGGAAGAAGTGGATCGAATCAAGCCGCTACATGCTGCATAA
ATGGCTATTCTTAATACTGCTGGCATGCAGCGCAAACCGACTCATCCTGGCGAAATGCTGAGGGAAGACTTTCTTCCGGA
CTATGGTCTGACGGTTTCGGGGTTGGCCGAATCTTTGGGTGTCTCTCGTCAGTCAGTGAATGAACTATTGCGGGAACGCC
GTGCTGTCAGCCCTGAAATGGCGCTCAGGCTTGCGCGTTTGTTTGGTAACTCGCCAGAATTCTGGCTGAACGCACAGCGG
TCTGTTGATCTTTGGACTGCTGCGCAGTCGGTCAAGGAAGAAGTGGATCGAATCAAGCCGCTACATGCTGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|