Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 378572..379920 Replicon chromosome
Accession NZ_AP022846
Organism Haemophilus influenzae strain TAMBA230

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag IGS56_RS01870 Protein ID WP_005667626.1
Coordinates 378889..379920 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag IGS56_RS01865 Protein ID WP_005667629.1
Coordinates 378572..378892 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGS56_RS01825 373994..374272 + 279 WP_103708107.1 cell division protein FtsB -
IGS56_RS01830 374272..374949 + 678 WP_114877243.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
IGS56_RS01835 374946..375422 + 477 WP_005650817.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
IGS56_RS01840 375728..376162 - 435 WP_006995247.1 D-tyrosyl-tRNA(Tyr) deacylase -
IGS56_RS01845 376159..376599 - 441 WP_005667635.1 FMN-binding protein MioC -
IGS56_RS01850 376696..376914 - 219 WP_005650820.1 cell division protein ZapB -
IGS56_RS01855 377076..378077 + 1002 WP_005667633.1 class II fructose-bisphosphatase -
IGS56_RS01860 378276..378584 + 309 WP_005661200.1 helix-turn-helix domain-containing protein -
IGS56_RS01865 378572..378892 + 321 WP_005667629.1 type II toxin-antitoxin system HipA family toxin Antitoxin
IGS56_RS01870 378889..379920 + 1032 WP_005667626.1 type II toxin-antitoxin system HipA family toxin Toxin
IGS56_RS01875 380003..381661 - 1659 WP_111688798.1 thiol reductant ABC exporter subunit CydC -
IGS56_RS01880 381654..383399 - 1746 WP_190811809.1 ABC transporter ATP-binding protein/permease -
IGS56_RS01885 383452..383673 - 222 WP_111688800.1 ABC transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39869.52 Da        Isoelectric Point: 6.4431

>T36577 WP_005667626.1 NZ_AP022846:378889-379920 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSINQQ
GNYILKPSPEEYPFLAENEHATMHIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKIAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFYTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEIIQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLHEPEL

Download         Length: 1032 bp

>T36577 NZ_AP022846:378889-379920 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGAGCACTTTGACAGCATAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACATGCCACCATGCACATTATGAA
AGAATTAGGGTTTGACGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACAGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAAATTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTTA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTATACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCATTACTTAACCTATTACATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12457.11 Da        Isoelectric Point: 5.9670

>AT36577 WP_005667629.1 NZ_AP022846:378572-378892 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT36577 NZ_AP022846:378572-378892 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTAGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References