Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2829692..2830349 Replicon chromosome
Accession NZ_AP022843
Organism Halomonas hydrothermalis strain Slthf2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HHSLTHF2_RS13125 Protein ID WP_172421467.1
Coordinates 2829692..2830036 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HHSLTHF2_RS13130 Protein ID WP_095603867.1
Coordinates 2830047..2830349 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHSLTHF2_RS13095 2824978..2825970 - 993 WP_172421463.1 helix-turn-helix domain-containing protein -
HHSLTHF2_RS13100 2826095..2826868 + 774 WP_172421464.1 HD domain-containing protein -
HHSLTHF2_RS13105 2827059..2827469 - 411 WP_197915462.1 PaaI family thioesterase -
HHSLTHF2_RS13110 2827522..2828148 - 627 WP_172421465.1 LysE family translocator -
HHSLTHF2_RS13115 2828372..2828953 - 582 WP_172421466.1 class I SAM-dependent methyltransferase -
HHSLTHF2_RS13120 2829061..2829396 - 336 WP_038477126.1 PhnA domain-containing protein -
HHSLTHF2_RS13125 2829692..2830036 + 345 WP_172421467.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHSLTHF2_RS13130 2830047..2830349 + 303 WP_095603867.1 XRE family transcriptional regulator Antitoxin
HHSLTHF2_RS13135 2830417..2832030 - 1614 WP_172421468.1 ATP-binding cassette domain-containing protein -
HHSLTHF2_RS13140 2832292..2833425 - 1134 WP_172421469.1 MFS transporter -
HHSLTHF2_RS13145 2833570..2834472 + 903 WP_172421470.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13190.98 Da        Isoelectric Point: 6.2305

>T36574 WP_172421467.1 NZ_AP022843:2829692-2830036 [Halomonas hydrothermalis]
MWSIEQTDTFEAWFFSLEEIERENVLASVLLLRERGPMLSRPHADTVNGSQHSNMKELRVQCQGRPIRVFFAFDPRRTGI
LLCAGDKGGNDKRFYNEMTPVADKEYTAHLETLK

Download         Length: 345 bp

>T36574 NZ_AP022843:2829692-2830036 [Halomonas hydrothermalis]
ATGTGGTCTATCGAGCAAACAGACACATTTGAAGCGTGGTTCTTCTCATTGGAAGAAATTGAACGTGAGAACGTTCTGGC
TTCTGTACTTCTTCTACGTGAACGAGGCCCGATGCTTTCAAGGCCGCACGCTGACACTGTAAATGGCTCGCAGCATTCCA
ACATGAAGGAATTGCGTGTTCAGTGCCAGGGACGTCCTATTAGAGTATTTTTTGCGTTTGACCCACGTCGCACAGGCATC
TTGCTATGCGCAGGCGATAAAGGTGGAAATGACAAGCGCTTCTATAATGAGATGACTCCAGTCGCCGATAAAGAATATAC
GGCTCACCTGGAAACACTAAAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10992.78 Da        Isoelectric Point: 6.4757

>AT36574 WP_095603867.1 NZ_AP022843:2830047-2830349 [Halomonas hydrothermalis]
MARKLEDLLAREKPEIVAAAEAKANDMLFEIRLAEIRQLAEKTQADIAIAMGVKQPTVAGLEKVGQDMRLSSLKRYVEAL
GGRVRVDIELPDGSHHGFPV

Download         Length: 303 bp

>AT36574 NZ_AP022843:2830047-2830349 [Halomonas hydrothermalis]
ATGGCACGCAAACTGGAAGACTTGTTAGCAAGAGAAAAGCCAGAGATCGTTGCGGCAGCTGAAGCGAAAGCCAACGATAT
GTTATTCGAGATCAGGCTTGCCGAAATTCGTCAGCTAGCGGAGAAAACCCAAGCAGATATAGCTATTGCGATGGGAGTAA
AACAACCCACCGTCGCAGGACTTGAGAAAGTTGGCCAGGATATGCGCCTTAGTTCACTCAAACGCTACGTCGAAGCGCTA
GGCGGCCGAGTCCGTGTCGATATAGAACTTCCCGATGGAAGTCATCATGGCTTCCCTGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References