Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 756671..757242 Replicon chromosome
Accession NZ_AP022843
Organism Halomonas hydrothermalis strain Slthf2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HHSLTHF2_RS03710 Protein ID WP_172420040.1
Coordinates 756671..756949 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HHSLTHF2_RS03715 Protein ID WP_009722157.1
Coordinates 756949..757242 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHSLTHF2_RS03680 752729..753358 + 630 WP_172420036.1 hypothetical protein -
HHSLTHF2_RS03685 753355..754584 + 1230 WP_172420037.1 hypothetical protein -
HHSLTHF2_RS03690 754581..755447 + 867 WP_172420038.1 hypothetical protein -
HHSLTHF2_RS03695 755515..755793 + 279 WP_197915485.1 hypothetical protein -
HHSLTHF2_RS03700 755867..756157 - 291 WP_172420039.1 type II toxin-antitoxin system RelE/ParE family toxin -
HHSLTHF2_RS03705 756150..756371 - 222 WP_120385726.1 hypothetical protein -
HHSLTHF2_RS03710 756671..756949 + 279 WP_172420040.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHSLTHF2_RS03715 756949..757242 + 294 WP_009722157.1 HigA family addiction module antidote protein Antitoxin
HHSLTHF2_RS03720 757359..758321 + 963 WP_172420041.1 ribonuclease Z -
HHSLTHF2_RS03725 758337..758591 - 255 WP_172420042.1 Txe/YoeB family addiction module toxin -
HHSLTHF2_RS03730 758588..758839 - 252 WP_172420043.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
HHSLTHF2_RS03735 759003..760199 - 1197 WP_172420044.1 homoserine O-acetyltransferase -
HHSLTHF2_RS03740 760275..761447 - 1173 WP_172420045.1 UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10767.33 Da        Isoelectric Point: 10.1580

>T36571 WP_172420040.1 NZ_AP022843:756671-756949 [Halomonas hydrothermalis]
MIKSFRHKGLKRFYASGSTAGIQADHAKKLRMQLAALDTAVSVEDMDIPGFRLHPLKGRYKGRWSIWINGNWRMTFEFRD
GNAYILDYEDYH

Download         Length: 279 bp

>T36571 NZ_AP022843:756671-756949 [Halomonas hydrothermalis]
ATGATTAAATCATTCCGCCACAAGGGACTCAAGCGGTTCTACGCTAGTGGCAGCACCGCTGGTATACAGGCGGATCATGC
CAAGAAATTGCGTATGCAGCTTGCCGCTCTGGACACGGCCGTGTCAGTAGAAGATATGGATATCCCTGGTTTTAGGCTCC
ACCCGTTGAAGGGGAGATACAAAGGGCGGTGGTCAATTTGGATCAACGGAAATTGGCGCATGACGTTCGAATTTCGAGAT
GGCAATGCGTACATTCTTGATTATGAGGATTATCACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10879.43 Da        Isoelectric Point: 4.7164

>AT36571 WP_009722157.1 NZ_AP022843:756949-757242 [Halomonas hydrothermalis]
MTMHNPPHPGEFIREVYLEPFGISSRQLASNLGVSPSTLSRLLKGDSGISPEMSLRLSKVLGRTPESWLSMQDMYDLWMA
RSTINLDDLQPLDFEAA

Download         Length: 294 bp

>AT36571 NZ_AP022843:756949-757242 [Halomonas hydrothermalis]
ATGACGATGCATAATCCGCCGCATCCCGGCGAATTTATTCGGGAAGTGTACCTAGAACCTTTTGGTATCAGCTCCCGCCA
GCTTGCTTCCAACTTGGGCGTTTCACCATCCACCTTGTCACGGTTGCTCAAAGGGGATAGTGGCATTAGCCCCGAAATGT
CTTTGCGCTTGTCGAAGGTTCTCGGACGTACCCCGGAGAGCTGGCTATCAATGCAGGACATGTATGACCTATGGATGGCT
CGCAGCACAATTAATTTGGACGACCTGCAGCCATTGGACTTTGAGGCCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References