Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2338526..2339172 Replicon chromosome
Accession NZ_AP022821
Organism Halomonas meridiana strain Slthf1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HMSLTHF_RS11075 Protein ID WP_063744303.1
Coordinates 2338526..2338717 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HMSLTHF_RS11080 Protein ID WP_058577260.1
Coordinates 2338717..2339172 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMSLTHF_RS11050 2333640..2334473 + 834 WP_062363386.1 glycosyl transferase -
HMSLTHF_RS11055 2334520..2335770 - 1251 WP_172416322.1 O-antigen ligase family protein -
HMSLTHF_RS11060 2335831..2337267 - 1437 WP_172416323.1 MBL fold metallo-hydrolase -
HMSLTHF_RS11065 2337379..2337735 - 357 WP_137094612.1 hypothetical protein -
HMSLTHF_RS11070 2337698..2338451 - 754 Protein_2157 IS630 family transposase -
HMSLTHF_RS11075 2338526..2338717 + 192 WP_063744303.1 type II toxin-antitoxin system HigB family toxin Toxin
HMSLTHF_RS11080 2338717..2339172 + 456 WP_058577260.1 hypothetical protein Antitoxin
HMSLTHF_RS11085 2339236..2339448 - 213 WP_172416324.1 hypothetical protein -
HMSLTHF_RS11090 2339504..2340283 - 780 WP_172416325.1 SapC family protein -
HMSLTHF_RS11095 2340374..2342914 - 2541 WP_172416326.1 DUF4214 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2338080..2338451 371


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(1-53)

Antitoxin

Antitoxin HigA

(5-139)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7641.02 Da        Isoelectric Point: 10.1415

>T36551 WP_063744303.1 NZ_AP022821:2338526-2338717 [Halomonas meridiana]
MKAMFPSLDNFKYVDKWWVVDIGGNNLRLIAFIDFEKQRLFTKHLVTHVMYNTLCKKYAQEKR

Download         Length: 192 bp

>T36551 NZ_AP022821:2338526-2338717 [Halomonas meridiana]
ATGAAAGCCATGTTTCCAAGCCTAGATAACTTCAAATACGTGGACAAATGGTGGGTGGTTGACATAGGGGGTAATAATCT
GAGGCTTATTGCCTTTATAGACTTTGAAAAACAACGGTTGTTTACCAAGCACCTAGTGACTCACGTCATGTACAACACAC
TGTGCAAAAAATACGCACAGGAGAAGAGATAA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 17221.41 Da        Isoelectric Point: 4.2022

>AT36551 WP_058577260.1 NZ_AP022821:2338717-2339172 [Halomonas meridiana]
MNAIAIIQPADKLFKEAPFLVRIHHHAEYEDALALVETLLDEENEDNDFLIERLTDVIEEWEDTAPELSTFNESLSALDG
VDMLKFLMEQNDLGTADLPEIGSKSYVSKVLNRKRELTRRHIEALSARFRVEPALFLADNEWPIGQGEALK

Download         Length: 456 bp

>AT36551 NZ_AP022821:2338717-2339172 [Halomonas meridiana]
ATGAACGCAATCGCTATTATCCAACCCGCTGACAAGCTATTTAAAGAAGCGCCCTTCCTCGTGAGAATCCATCATCACGC
CGAGTATGAAGACGCTCTGGCCTTAGTAGAAACGCTGCTAGACGAGGAAAATGAGGATAATGACTTTCTCATTGAGCGGC
TGACCGATGTTATCGAGGAGTGGGAAGACACGGCTCCTGAGCTCTCAACTTTTAACGAATCCCTATCGGCGCTGGATGGC
GTGGATATGCTGAAATTTCTAATGGAGCAGAACGACTTAGGTACTGCCGATCTTCCCGAAATCGGCAGCAAATCTTATGT
CTCAAAAGTGCTTAATCGAAAACGCGAACTGACACGTCGCCATATTGAGGCATTATCAGCCCGCTTTAGGGTCGAACCTG
CCCTATTTTTAGCCGATAATGAATGGCCTATTGGGCAAGGTGAGGCGCTCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References