Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 15567..15825 Replicon chromosome
Accession NZ_AP022650
Organism Escherichia coli strain 09-02E

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag HRS14_RS00075 Protein ID WP_000809168.1
Coordinates 15567..15719 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 15768..15825 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS14_RS00055 10812..11525 - 714 WP_001102391.1 acidic protein MsyB -
HRS14_RS00060 11551..11955 - 405 WP_000843687.1 DUF2541 family protein -
HRS14_RS00065 12327..14243 + 1917 WP_000516135.1 molecular chaperone DnaK -
HRS14_RS00070 14332..15462 + 1131 WP_001118464.1 molecular chaperone DnaJ -
HRS14_RS00075 15567..15719 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 15768..15825 + 58 - - Antitoxin
HRS14_RS00080 16334..17095 + 762 WP_001274832.1 hypothetical protein -
HRS14_RS00085 17115..18608 + 1494 WP_001774152.1 sulfatase-like hydrolase/transferase -
HRS14_RS00090 18737..19996 + 1260 WP_000494929.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T36448 WP_000809168.1 NZ_AP022650:c15719-15567 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T36448 NZ_AP022650:c15719-15567 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT36448 NZ_AP022650:15768-15825 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References