Detailed information of TA system TA036381

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1548483..1548982
• Replicon: chromosome
• Accession: NZ_AP022615
• Organism: Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: G6N25_RS07440
• Protein ID: WP_083074154.1
• Coordinates: 1548725..1548982 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: G6N25_RS07435
• Protein ID: WP_083074155.1
• Coordinates: 1548483..1548728 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N25_RS07420	1543561..1546107	-	2547	WP_083074236.1	ATP-dependent chaperone ClpB	-
G6N25_RS07425	1546318..1547469	+	1152	WP_083074157.1	2-polyprenylphenol hydroxylase	-
G6N25_RS07430	1547548..1548438	+	891	WP_083074156.1	aldose 1-epimerase	-
G6N25_RS07435	1548483..1548728	+	246	WP_083074155.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
G6N25_RS07440	1548725..1548982	+	258	WP_083074154.1	Txe/YoeB family addiction module toxin	Toxin
G6N25_RS07445	1549163..1549552	-	390	WP_083074153.1	helix-turn-helix domain-containing protein	-
G6N25_RS07450	1549552..1550727	-	1176	WP_083074152.1	molecular chaperone DnaJ	-
G6N25_RS07455	1550806..1551441	-	636	WP_083074151.1	nucleotide exchange factor GrpE	-
G6N25_RS07460	1551438..1553297	-	1860	WP_083074150.1	molecular chaperone DnaK	-
G6N25_RS07465	1553522..1553887	-	366	WP_142272636.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10001.26 Da
• Isoelectric Point: 7.1997

>T36381 WP_083074154.1 NZ_AP022615:1548725-1548982 [Mycobacterium heidelbergense]
VRLVFTPHGWADYQYWSTTDRGTQERINRLIDDILRDPFAGTGKPEPLRPAFAGAWSRRISEEHRLVYLVDGDDVVMMQA
RYRYT

Nucleotide

• Length: 258 bp

>T36381 NZ_AP022615:1548725-1548982 [Mycobacterium heidelbergense]
GTGAGGCTGGTCTTCACGCCTCACGGATGGGCCGACTACCAGTACTGGAGCACGACCGACCGGGGGACACAGGAGCGCAT
CAACCGCCTCATCGACGACATCTTGCGCGATCCGTTCGCCGGGACTGGCAAACCCGAACCGTTACGCCCCGCTTTCGCGG
GCGCCTGGTCACGGCGCATCAGCGAGGAACACCGCTTGGTGTACCTCGTCGACGGCGACGACGTCGTGATGATGCAGGCT
CGGTATCGCTACACCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9133.22 Da
• Isoelectric Point: 6.4705

>AT36381 WP_083074155.1 NZ_AP022615:1548483-1548728 [Mycobacterium heidelbergense]
VAITASEARKNLFPLIEQVNNDRVPVEINSRRGDAVLISRADYEALEETAHLLRSPANARRLLESLAQAQRGEREEHTLS
R

Nucleotide

• Length: 246 bp

>AT36381 NZ_AP022615:1548483-1548728 [Mycobacterium heidelbergense]
GTGGCGATCACCGCGTCTGAGGCACGCAAGAACCTATTTCCGTTGATCGAGCAGGTCAACAACGACCGTGTCCCGGTGGA
GATCAACTCCCGCCGGGGTGATGCGGTATTGATCTCCCGCGCCGACTACGAAGCCCTGGAAGAGACCGCACACCTGTTGC
GGTCCCCGGCTAACGCACGTCGACTGCTGGAGAGCCTCGCCCAGGCGCAGCGTGGCGAGCGCGAAGAGCACACGCTGTCC
CGGTGA