Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1123941..1124659 Replicon chromosome
Accession NZ_AP022615
Organism Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag G6N25_RS05265 Protein ID WP_083075119.1
Coordinates 1123941..1124354 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag G6N25_RS05270 Protein ID WP_083075077.1
Coordinates 1124351..1124659 (+) Length 103 a.a.

Genomic Context

G6N25_RS05240G6N25_RS05260G6N25_RS05265G6N25_RS05270G6N25_RS05295G6N25_RS05300G6N25_RS05245G6N25_RS05250G6N25_RS05255G6N25_RS05275G6N25_RS05280G6N25_RS05285G6N25_RS05290
Location: 1120380..1120790 (411 bp)
Type: Others
Protein ID: WP_083075087.1
Location: 1123444..1123740 (297 bp)
Type: Others
Protein ID: WP_083075079.1
Location: 1123941..1124354 (414 bp)
Type: Toxin
Protein ID: WP_083075119.1
Location: 1124351..1124659 (309 bp)
Type: Antitoxin
Protein ID: WP_083075077.1
Location: 1127933..1128157 (225 bp)
Type: Others
Protein ID: WP_083075068.1
Location: 1128148..1128558 (411 bp)
Type: Others
Protein ID: WP_083075066.1
Location: 1120818..1121615 (798 bp)
Type: Others
Protein ID: WP_083075085.1
Location: 1121608..1122183 (576 bp)
Type: Others
Protein ID: WP_083075083.1
Location: 1122265..1123053 (789 bp)
Type: Others
Protein ID: WP_083075081.1
Location: 1124648..1125862 (1215 bp)
Type: Others
Protein ID: WP_083075075.1
Location: 1126026..1126487 (462 bp)
Type: Others
Protein ID: WP_142272723.1
Location: 1127242..1127493 (252 bp)
Type: Others
Protein ID: WP_083075072.1
Location: 1127490..1127762 (273 bp)
Type: Others
Protein ID: WP_083075070.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G6N25_RS052401120380..1120790+411WP_083075087.1DUF5319 domain-containing protein-
G6N25_RS052451120818..1121615-798WP_083075085.1hypothetical protein-
G6N25_RS052501121608..1122183-576WP_083075083.1sigma-70 family RNA polymerase sigma factor-
G6N25_RS052551122265..1123053-789WP_083075081.1hypothetical protein-
G6N25_RS052601123444..1123740+297WP_083075079.1WhiB family transcriptional regulator-
G6N25_RS052651123941..1124354+414WP_083075119.1type II toxin-antitoxin system RelE/ParE family toxinToxin
G6N25_RS052701124351..1124659+309WP_083075077.1XRE family transcriptional regulatorAntitoxin
G6N25_RS052751124648..1125862-1215WP_083075075.1cytochrome P450-
G6N25_RS052801126026..1126487-462WP_142272723.1hypothetical protein-
G6N25_RS052851127242..1127493-252WP_083075072.1type II toxin-antitoxin system RelE/ParE family toxin-
G6N25_RS052901127490..1127762-273WP_083075070.1type II toxin-antitoxin system Phd/YefM family antitoxin-
G6N25_RS052951127933..1128157+225WP_083075068.1hypothetical protein-
G6N25_RS053001128148..1128558+411WP_083075066.1PIN domain nuclease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-87)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15755.08 Da        Isoelectric Point: 9.4062

>T36377 WP_083075119.1 NZ_AP022615:1123941-1124354 [Mycobacterium heidelbergense]
MRKWEVDLTLIEAWMDALDDDEYDNLIAALEQLEEHGPVTRRPFVDTIEGSKHPNMKELRPRATKAGAYIRVLFAFDIRS
RAIMLIAGDKAGNWSKWYAKHIPIADDLFTAHQKGLHREEAEATKAMNPKARKGKKR

Download         Length: 414 bp

>T36377 NZ_AP022615:1123941-1124354 [Mycobacterium heidelbergense]
ATGCGGAAATGGGAGGTCGATCTGACCCTCATCGAAGCCTGGATGGACGCGCTCGACGACGACGAATACGACAACTTGAT
AGCAGCGCTGGAGCAGTTGGAGGAACACGGCCCAGTAACCCGGCGACCGTTCGTGGACACCATCGAGGGGTCAAAGCATC
CGAACATGAAAGAGCTTCGTCCGCGCGCCACGAAGGCCGGAGCCTACATTCGTGTGCTGTTCGCCTTCGATATCAGATCG
CGGGCAATCATGCTGATCGCTGGAGACAAGGCGGGGAATTGGTCCAAGTGGTATGCCAAGCACATCCCCATCGCCGACGA
CCTGTTCACTGCCCATCAGAAGGGTCTGCATAGGGAGGAAGCCGAAGCAACCAAAGCCATGAATCCGAAGGCAAGGAAGG
GGAAGAAACGATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11502.01 Da        Isoelectric Point: 10.3882

>AT36377 WP_083075077.1 NZ_AP022615:1124351-1124659 [Mycobacterium heidelbergense]
MTNLDDMRRRRPGNRTRIDAIKAEMDREVTQYRLRELREAAGFTQTTLAAAIGVGQNRVSQMEHGELGTSRVDTLRRYVE
ATGGELEVSVKRPDGSRVLLSL

Download         Length: 309 bp

>AT36377 NZ_AP022615:1124351-1124659 [Mycobacterium heidelbergense]
ATGACCAATCTCGACGATATGCGCCGTCGTCGCCCGGGCAACCGGACCCGTATTGACGCGATCAAGGCCGAGATGGACCG
CGAAGTCACCCAGTATCGTCTCCGTGAACTGCGCGAGGCCGCTGGCTTCACGCAGACGACCCTCGCTGCGGCTATTGGCG
TTGGCCAGAACCGTGTCTCCCAGATGGAGCACGGCGAGCTGGGCACTAGTCGTGTGGACACTCTCCGTAGGTACGTTGAG
GCGACGGGCGGTGAACTGGAGGTCTCCGTGAAGCGTCCGGACGGTTCACGGGTCCTCCTAAGTCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References