Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 996661..997337 Replicon chromosome
Accession NZ_AP022605
Organism Mycolicibacterium doricum strain JCM 12405

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G6N07_RS04965 Protein ID WP_085190014.1
Coordinates 996987..997337 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G6N07_RS04960 Protein ID WP_085190015.1
Coordinates 996661..996984 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N07_RS04955 994113..996563 + 2451 WP_085190017.1 AAA family ATPase -
G6N07_RS04960 996661..996984 - 324 WP_085190015.1 XRE family transcriptional regulator Antitoxin
G6N07_RS04965 996987..997337 - 351 WP_085190014.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6N07_RS04970 997373..998716 - 1344 WP_109749304.1 site-specific integrase -
G6N07_RS04975 998713..998898 - 186 WP_082967898.1 helix-turn-helix domain-containing protein -
G6N07_RS04980 999369..1000643 + 1275 Protein_983 relaxase domain-containing protein -
G6N07_RS04985 1000695..1001965 + 1271 WP_099050197.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 993486..1022393 28907


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13076.82 Da        Isoelectric Point: 4.8781

>T36321 WP_085190014.1 NZ_AP022605:c997337-996987 [Mycolicibacterium doricum]
MAWAVLLLEEVERWYFTLDDDTMTSVTGAIDLLEAEGPALGRPTVDRVNGSKFHNMKELRPAGTSVRILFIFDPQRQAIL
LLGGDKAGNWRSWYDKNIPVADERYARWLATGHGGE

Download         Length: 351 bp

>T36321 NZ_AP022605:c997337-996987 [Mycolicibacterium doricum]
ATGGCGTGGGCGGTACTCCTGCTGGAGGAGGTCGAACGGTGGTACTTCACGCTGGACGACGACACGATGACGTCGGTGAC
TGGCGCCATCGACCTACTCGAGGCGGAGGGGCCCGCCTTGGGCCGGCCGACGGTGGACCGGGTAAACGGGTCGAAGTTCC
ACAACATGAAGGAGCTGCGTCCCGCCGGTACGAGCGTCCGCATCCTGTTCATCTTCGATCCGCAACGCCAGGCGATTCTG
CTGCTCGGCGGAGACAAGGCCGGGAACTGGAGAAGCTGGTACGACAAGAACATCCCGGTCGCCGACGAGCGTTACGCCAG
ATGGCTGGCGACCGGCCACGGAGGTGAGTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11614.09 Da        Isoelectric Point: 8.6743

>AT36321 WP_085190015.1 NZ_AP022605:c996984-996661 [Mycolicibacterium doricum]
MARNWREIRAEAVEQGRVDPARADSARKKMHEAVQAYRLAEIRKAHGHARQADVAALMGVSQARVSQLESGDLAHTELGT
LQSYVAALGGHLRIVADFGGQTVELNA

Download         Length: 324 bp

>AT36321 NZ_AP022605:c996984-996661 [Mycolicibacterium doricum]
ATGGCGCGCAACTGGCGTGAGATCCGGGCCGAGGCGGTGGAACAAGGTCGCGTCGACCCGGCACGCGCGGACTCGGCACG
CAAGAAGATGCACGAAGCCGTCCAGGCCTATCGTCTCGCCGAGATTCGCAAGGCACACGGTCATGCTCGCCAGGCCGACG
TCGCGGCGCTCATGGGCGTCTCGCAGGCGCGGGTGTCGCAGCTCGAGAGTGGCGACCTGGCGCACACGGAGTTGGGGACG
TTGCAATCCTACGTGGCCGCACTCGGCGGGCACCTGCGGATTGTTGCCGATTTCGGCGGCCAGACAGTCGAGCTGAACGC
CTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References