Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3716723..3717399 Replicon chromosome
Accession NZ_AP022600
Organism Mycolicibacterium tokaiense strain JCM 6373

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G6N58_RS18065 Protein ID WP_115277798.1
Coordinates 3717049..3717399 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G6N58_RS18060 Protein ID WP_115277799.1
Coordinates 3716723..3717046 (-) Length 108 a.a.

Genomic Context


G6N58_RS18050G6N58_RS18080G6N58_RS18060G6N58_RS18065G6N58_RS18070G6N58_RS18075
Location: 3713736..3715133 (1398 bp)
Type: Others
Protein ID: WP_115277800.1
Location: 3719434..3722209 (2776 bp)
Type: Others
Protein ID: Protein_3591
Location: 3716723..3717046 (324 bp)
Type: Antitoxin
Protein ID: WP_115277799.1
Location: 3717049..3717399 (351 bp)
Type: Toxin
Protein ID: WP_115277798.1
Location: 3717435..3718781 (1347 bp)
Type: Others
Protein ID: WP_115277797.1
Location: 3718778..3718963 (186 bp)
Type: Others
Protein ID: WP_082967898.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G6N58_RS180503713736..3715133+1398WP_115277800.1FAD-binding oxidoreductase-
G6N58_RS180603716723..3717046-324WP_115277799.1XRE family transcriptional regulatorAntitoxin
G6N58_RS180653717049..3717399-351WP_115277798.1type II toxin-antitoxin system RelE/ParE family toxinToxin
G6N58_RS180703717435..3718781-1347WP_115277797.1site-specific integrase-
G6N58_RS180753718778..3718963-186WP_082967898.1helix-turn-helix domain-containing protein-
G6N58_RS180803719434..3722209+2776Protein_3591relaxase domain-containing protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-105)

Antitoxin

(38-89)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 13068.84 Da        Isoelectric Point: 4.4346

>T36298 WP_115277798.1 NZ_AP022600:c3717399-3717049 [Mycolicibacterium tokaiense]
MAWVVLLLEEVERWYFTLDDDTMTSVTGAIDLLEAEGPALGRPTVDRVNGSTFHIMKELRPAGTSVRILFIFDPQRQAIL
LLGGDKAGNWRSWYDKNIPVADERYARWLATGEGGE

Download         Length: 351 bp

>T36298 NZ_AP022600:c3717399-3717049 [Mycolicibacterium tokaiense]
ATGGCGTGGGTGGTGCTCCTGCTGGAGGAGGTTGAACGGTGGTACTTCACGCTGGACGACGACACCATGACGTCGGTGAC
CGGGGCGATCGACTTACTCGAGGCGGAGGGGCCCGCCTTGGGCCGGCCCACGGTGGACCGGGTGAACGGCTCGACGTTCC
ACATCATGAAGGAGCTGCGTCCCGCCGGTACCAGCGTCCGCATCCTGTTCATCTTCGATCCGCAGCGACAGGCGATCCTG
CTGCTCGGCGGAGACAAGGCCGGGAACTGGCGAAGCTGGTACGACAAGAACATCCCGGTCGCGGACGAGCGTTATGCCAG
ATGGCTGGCGACCGGCGAGGGAGGTGAGTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11759.20 Da        Isoelectric Point: 6.9906

>AT36298 WP_115277799.1 NZ_AP022600:c3717046-3716723 [Mycolicibacterium tokaiense]
MARNWREIRAEAVEQGRVEPARADSARKQMHEAVQAYRLAEIRKAHGHARQADVAALMGVSQARVSQLESGDLAHTELRT
LQSYVAALGGHLRIVADFGEDSVELTA

Download         Length: 324 bp

>AT36298 NZ_AP022600:c3717046-3716723 [Mycolicibacterium tokaiense]
ATGGCACGCAATTGGCGTGAGATCCGAGCCGAGGCGGTGGAACAGGGTCGCGTGGAACCCGCACGCGCAGACTCGGCACG
CAAGCAGATGCATGAAGCCGTCCAGGCTTACCGTCTCGCCGAGATTCGGAAGGCGCACGGCCACGCTCGCCAGGCCGACG
TCGCGGCGCTCATGGGCGTCTCGCAGGCGCGGGTCTCGCAATTGGAGAGCGGCGACTTGGCGCATACGGAGTTGAGGACG
CTGCAGTCCTACGTCGCCGCACTCGGTGGACACTTGCGGATTGTTGCCGACTTCGGTGAGGACAGCGTCGAACTGACGGC
CTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
No matching records found

References