Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 3716723..3717399 | Replicon | chromosome |
Accession | NZ_AP022600 | ||
Organism | Mycolicibacterium tokaiense strain JCM 6373 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | G6N58_RS18065 | Protein ID | WP_115277798.1 |
Coordinates | 3717049..3717399 (-) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | G6N58_RS18060 | Protein ID | WP_115277799.1 |
Coordinates | 3716723..3717046 (-) | Length | 108 a.a. |
Genomic Context
Location: 3713736..3715133 (1398 bp)
Type: Others
Protein ID: WP_115277800.1
Type: Others
Protein ID: WP_115277800.1
Location: 3719434..3722209 (2776 bp)
Type: Others
Protein ID: Protein_3591
Type: Others
Protein ID: Protein_3591
Location: 3716723..3717046 (324 bp)
Type: Antitoxin
Protein ID: WP_115277799.1
Type: Antitoxin
Protein ID: WP_115277799.1
Location: 3717049..3717399 (351 bp)
Type: Toxin
Protein ID: WP_115277798.1
Type: Toxin
Protein ID: WP_115277798.1
Location: 3717435..3718781 (1347 bp)
Type: Others
Protein ID: WP_115277797.1
Type: Others
Protein ID: WP_115277797.1
Location: 3718778..3718963 (186 bp)
Type: Others
Protein ID: WP_082967898.1
Type: Others
Protein ID: WP_082967898.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
G6N58_RS18050 | 3713736..3715133 | + | 1398 | WP_115277800.1 | FAD-binding oxidoreductase | - |
G6N58_RS18060 | 3716723..3717046 | - | 324 | WP_115277799.1 | XRE family transcriptional regulator | Antitoxin |
G6N58_RS18065 | 3717049..3717399 | - | 351 | WP_115277798.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
G6N58_RS18070 | 3717435..3718781 | - | 1347 | WP_115277797.1 | site-specific integrase | - |
G6N58_RS18075 | 3718778..3718963 | - | 186 | WP_082967898.1 | helix-turn-helix domain-containing protein | - |
G6N58_RS18080 | 3719434..3722209 | + | 2776 | Protein_3591 | relaxase domain-containing protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13068.84 Da Isoelectric Point: 4.4346
>T36298 WP_115277798.1 NZ_AP022600:c3717399-3717049 [Mycolicibacterium tokaiense]
MAWVVLLLEEVERWYFTLDDDTMTSVTGAIDLLEAEGPALGRPTVDRVNGSTFHIMKELRPAGTSVRILFIFDPQRQAIL
LLGGDKAGNWRSWYDKNIPVADERYARWLATGEGGE
MAWVVLLLEEVERWYFTLDDDTMTSVTGAIDLLEAEGPALGRPTVDRVNGSTFHIMKELRPAGTSVRILFIFDPQRQAIL
LLGGDKAGNWRSWYDKNIPVADERYARWLATGEGGE
Download Length: 351 bp
>T36298 NZ_AP022600:c3717399-3717049 [Mycolicibacterium tokaiense]
ATGGCGTGGGTGGTGCTCCTGCTGGAGGAGGTTGAACGGTGGTACTTCACGCTGGACGACGACACCATGACGTCGGTGAC
CGGGGCGATCGACTTACTCGAGGCGGAGGGGCCCGCCTTGGGCCGGCCCACGGTGGACCGGGTGAACGGCTCGACGTTCC
ACATCATGAAGGAGCTGCGTCCCGCCGGTACCAGCGTCCGCATCCTGTTCATCTTCGATCCGCAGCGACAGGCGATCCTG
CTGCTCGGCGGAGACAAGGCCGGGAACTGGCGAAGCTGGTACGACAAGAACATCCCGGTCGCGGACGAGCGTTATGCCAG
ATGGCTGGCGACCGGCGAGGGAGGTGAGTAG
ATGGCGTGGGTGGTGCTCCTGCTGGAGGAGGTTGAACGGTGGTACTTCACGCTGGACGACGACACCATGACGTCGGTGAC
CGGGGCGATCGACTTACTCGAGGCGGAGGGGCCCGCCTTGGGCCGGCCCACGGTGGACCGGGTGAACGGCTCGACGTTCC
ACATCATGAAGGAGCTGCGTCCCGCCGGTACCAGCGTCCGCATCCTGTTCATCTTCGATCCGCAGCGACAGGCGATCCTG
CTGCTCGGCGGAGACAAGGCCGGGAACTGGCGAAGCTGGTACGACAAGAACATCCCGGTCGCGGACGAGCGTTATGCCAG
ATGGCTGGCGACCGGCGAGGGAGGTGAGTAG
Antitoxin
Download Length: 108 a.a. Molecular weight: 11759.20 Da Isoelectric Point: 6.9906
>AT36298 WP_115277799.1 NZ_AP022600:c3717046-3716723 [Mycolicibacterium tokaiense]
MARNWREIRAEAVEQGRVEPARADSARKQMHEAVQAYRLAEIRKAHGHARQADVAALMGVSQARVSQLESGDLAHTELRT
LQSYVAALGGHLRIVADFGEDSVELTA
MARNWREIRAEAVEQGRVEPARADSARKQMHEAVQAYRLAEIRKAHGHARQADVAALMGVSQARVSQLESGDLAHTELRT
LQSYVAALGGHLRIVADFGEDSVELTA
Download Length: 324 bp
>AT36298 NZ_AP022600:c3717046-3716723 [Mycolicibacterium tokaiense]
ATGGCACGCAATTGGCGTGAGATCCGAGCCGAGGCGGTGGAACAGGGTCGCGTGGAACCCGCACGCGCAGACTCGGCACG
CAAGCAGATGCATGAAGCCGTCCAGGCTTACCGTCTCGCCGAGATTCGGAAGGCGCACGGCCACGCTCGCCAGGCCGACG
TCGCGGCGCTCATGGGCGTCTCGCAGGCGCGGGTCTCGCAATTGGAGAGCGGCGACTTGGCGCATACGGAGTTGAGGACG
CTGCAGTCCTACGTCGCCGCACTCGGTGGACACTTGCGGATTGTTGCCGACTTCGGTGAGGACAGCGTCGAACTGACGGC
CTGA
ATGGCACGCAATTGGCGTGAGATCCGAGCCGAGGCGGTGGAACAGGGTCGCGTGGAACCCGCACGCGCAGACTCGGCACG
CAAGCAGATGCATGAAGCCGTCCAGGCTTACCGTCTCGCCGAGATTCGGAAGGCGCACGGCCACGCTCGCCAGGCCGACG
TCGCGGCGCTCATGGGCGTCTCGCAGGCGCGGGTCTCGCAATTGGAGAGCGGCGACTTGGCGCATACGGAGTTGAGGACG
CTGCAGTCCTACGTCGCCGCACTCGGTGGACACTTGCGGATTGTTGCCGACTTCGGTGAGGACAGCGTCGAACTGACGGC
CTGA