36264

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2900084..2900654 Replicon chromosome
Accession NZ_AP022589
Organism Mycolicibacter minnesotensis strain JCM 17932

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag G6N09_RS13470 Protein ID WP_083027004.1
Coordinates 2900084..2900365 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G6N09_RS13475 Protein ID WP_083027003.1
Coordinates 2900352..2900654 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N09_RS13455 2895434..2897161 - 1728 Protein_2658 SulP family inorganic anion transporter -
G6N09_RS13460 2897706..2898857 - 1152 WP_179959834.1 hypothetical protein -
G6N09_RS13465 2898976..2900049 + 1074 WP_083027005.1 redox-regulated ATPase YchF -
G6N09_RS13470 2900084..2900365 + 282 WP_083027004.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6N09_RS13475 2900352..2900654 + 303 WP_083027003.1 HigA family addiction module antidote protein Antitoxin
G6N09_RS13480 2900651..2901136 + 486 WP_083027002.1 pyridoxamine 5'-phosphate oxidase family protein -
G6N09_RS13485 2901324..2901515 + 192 Protein_2664 PhnA domain-containing protein -
G6N09_RS13490 2901666..2902673 + 1008 WP_083027000.1 alpha/beta hydrolase -
G6N09_RS13495 2902763..2903074 + 312 WP_179959835.1 hypothetical protein -
G6N09_RS13500 2903011..2903421 - 411 WP_083026999.1 NAD(+)--rifampin ADP-ribosyltransferase -
G6N09_RS13505 2903462..2903932 + 471 WP_083027052.1 acetyltransferase -
G6N09_RS13510 2904125..2904478 - 354 WP_083026998.1 Fe-S protein -
G6N09_RS13515 2904581..2905093 + 513 WP_083026997.1 OsmC family protein -
G6N09_RS13520 2905100..2905492 - 393 WP_083026996.1 nitroreductase family deazaflavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10852.26 Da        Isoelectric Point: 10.5604

>T36264 WP_083027004.1 NZ_AP022589:2900084-2900365 [Mycolicibacter minnesotensis]
VIRSFGSKDTERLSRRERVRSLDPQIQRAALRKLRQVGSAVTLEDLRLPPGNRLERLKGDRSGQHSIRINDQWRICFTWT
DAGPEEVEIVDYH

Download         Length: 282 bp

>T36264 NZ_AP022589:2900084-2900365 [Mycolicibacter minnesotensis]
GTGATCAGGTCCTTTGGGAGCAAGGACACTGAGCGGCTTTCGCGTCGTGAACGTGTTCGTTCGTTGGACCCACAGATCCA
ACGGGCAGCGCTACGGAAGCTGCGTCAAGTCGGCTCGGCGGTCACGCTCGAAGACCTCCGACTGCCGCCGGGCAATCGGC
TTGAGCGACTCAAGGGCGATCGATCTGGTCAGCACAGCATCAGAATCAACGACCAGTGGCGGATCTGCTTCACATGGACC
GACGCTGGACCGGAGGAGGTGGAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11046.56 Da        Isoelectric Point: 6.6420

>AT36264 WP_083027003.1 NZ_AP022589:2900352-2900654 [Mycolicibacter minnesotensis]
MTTTDKHPPIHPGEILHEDFLEGFGVTQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSAQFWLNLQSHYDL
DLAEDRVADQIAAITPLKSA

Download         Length: 303 bp

>AT36264 NZ_AP022589:2900352-2900654 [Mycolicibacter minnesotensis]
TTGACTACCACTGACAAGCACCCGCCGATCCACCCCGGAGAGATCCTTCACGAGGACTTCCTGGAAGGCTTCGGCGTCAC
CCAGAACAAACTCGCGGTGTCGATCGGAGTTCCGCCCCGGCGCATCAACGAGATCGTGCACGGTAAGCGCGGCATCACCG
CGGACACCGCATTGCGGCTGGCGAAGTATTTCGGTACCTCGGCCCAGTTCTGGCTCAATCTTCAGTCGCACTACGACCTC
GACCTCGCCGAGGATCGGGTTGCCGATCAGATCGCTGCGATCACTCCGCTGAAGAGCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References