Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4417218..4417810 Replicon chromosome
Accession NZ_AP022570
Organism Mycolicibacterium poriferae strain JCM 12603

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag G6N39_RS20815 Protein ID WP_152517893.1
Coordinates 4417529..4417810 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G6N39_RS20810 Protein ID WP_152517892.1
Coordinates 4417218..4417514 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N39_RS20795 4413855..4415510 - 1656 WP_163680579.1 HAD-IB family hydrolase -
G6N39_RS20800 4415540..4417015 - 1476 WP_163677218.1 wax ester/triacylglycerol synthase family O-acyltransferase -
G6N39_RS20810 4417218..4417514 - 297 WP_152517892.1 HigA family addiction module antidote protein Antitoxin
G6N39_RS20815 4417529..4417810 - 282 WP_152517893.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6N39_RS20820 4417964..4418635 - 672 WP_163677221.1 arsenate reductase ArsC -
G6N39_RS20825 4418625..4419746 - 1122 WP_163677224.1 ACR3 family arsenite efflux transporter -
G6N39_RS20830 4419743..4420117 - 375 WP_163677229.1 metalloregulator ArsR/SmtB family transcription factor -
G6N39_RS20835 4420193..4420609 - 417 WP_163677232.1 VOC family protein -
G6N39_RS20840 4420708..4421067 + 360 WP_163677235.1 metalloregulator ArsR/SmtB family transcription factor -
G6N39_RS20845 4421194..4421430 + 237 WP_163677238.1 CsbD family protein -
G6N39_RS20850 4421475..4422077 - 603 WP_163680582.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-81)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10662.97 Da        Isoelectric Point: 8.0375

>T36175 WP_152517893.1 NZ_AP022570:c4417810-4417529 [Mycolicibacterium poriferae]
VIRSFSDSDTQKVWELGRPKGISTTLAKAARRKMQILDAAENINDLRVPPGNRLEKLQPPREGQHSIRVNDQYRLCFTWR
DGGADDVELTDYH

Download         Length: 282 bp

>T36175 NZ_AP022570:c4417810-4417529 [Mycolicibacterium poriferae]
GTGATCCGTTCGTTCAGCGACAGCGACACCCAGAAGGTCTGGGAGCTGGGACGGCCGAAAGGGATCAGCACCACGCTGGC
CAAGGCGGCGCGCCGCAAAATGCAGATCCTCGACGCAGCCGAGAACATCAACGACCTCCGCGTCCCGCCGGGCAACCGGC
TGGAGAAACTACAGCCGCCCCGCGAGGGGCAGCACAGCATTCGAGTCAACGACCAATATCGCCTCTGCTTCACCTGGCGC
GACGGCGGCGCCGACGACGTCGAACTCACCGACTACCACTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10684.29 Da        Isoelectric Point: 5.0616

>AT36175 WP_152517892.1 NZ_AP022570:c4417514-4417218 [Mycolicibacterium poriferae]
MADLVPTHPGEILAEEFLVPMGISAYRLAQEIGVPQTRISEIIHGRRAITADTGLRLSRALGLSDMFWINMQARYDADLA
RAECGAELDRIHPLAAAG

Download         Length: 297 bp

>AT36175 NZ_AP022570:c4417514-4417218 [Mycolicibacterium poriferae]
ATGGCCGACTTGGTACCCACCCACCCCGGCGAAATTCTCGCCGAAGAGTTCTTGGTGCCGATGGGCATCAGCGCCTACCG
GCTGGCGCAGGAAATCGGCGTGCCCCAGACCCGGATCAGCGAGATCATCCACGGGCGGCGGGCCATCACCGCCGACACCG
GGCTGCGGCTCTCGCGCGCGCTGGGCCTGTCGGACATGTTCTGGATCAACATGCAGGCCCGCTACGACGCCGACCTTGCG
CGGGCTGAGTGTGGCGCCGAACTCGATCGCATCCACCCACTCGCCGCCGCGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References