Detailed information of TA system TA036138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1440877..1441541
• Replicon: chromosome
• Accession: NZ_AP022561
• Organism: Mycolicibacterium aichiense strain JCM 6376

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: G6N32_RS06970
• Protein ID: WP_115316631.1
• Coordinates: 1441203..1441541 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: G6N32_RS06965
• Protein ID: WP_115316632.1
• Coordinates: 1440877..1441206 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N32_RS06960	1437456..1440548	+	3093	WP_115316633.1	hypothetical protein	-
G6N32_RS06965	1440877..1441206	-	330	WP_115316632.1	XRE family transcriptional regulator	Antitoxin
G6N32_RS06970	1441203..1441541	-	339	WP_115316631.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6N32_RS06975	1441571..1442782	-	1212	Protein_1379	site-specific integrase	-
G6N32_RS06980	1442929..1443114	-	186	WP_115316630.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (9-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (41-93)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12640.42 Da
• Isoelectric Point: 4.7025

>T36138 WP_115316631.1 NZ_AP022561:c1441541-1441203 [Mycolicibacterium aichiense]
VILLDEVEQWFFSLDRETMAAVTGAIDLLELEGPTLGRPVVDKVNGSKFHSMKELRPAGTSIRVLFIFDPARQAILLLDG
DKAGDWKRWYDRNIPIADARFESWLATEHGGQ

Nucleotide

• Length: 339 bp

>T36138 NZ_AP022561:c1441541-1441203 [Mycolicibacterium aichiense]
GTGATCCTGCTCGACGAGGTCGAACAGTGGTTCTTCTCGCTCGACAGGGAGACGATGGCGGCGGTCACCGGTGCCATCGA
CCTGTTGGAGCTGGAGGGGCCGACACTGGGTCGGCCGGTCGTCGACAAGGTGAACGGCTCGAAGTTTCACAGCATGAAGG
AGCTGCGCCCCGCCGGCACCAGCATCCGCGTCCTGTTCATCTTCGACCCGGCCCGGCAGGCGATCCTGCTCCTGGACGGC
GACAAGGCAGGCGACTGGAAGCGCTGGTACGACAGGAACATTCCGATCGCGGATGCACGTTTCGAGAGCTGGCTGGCGAC
CGAGCACGGAGGGCAATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11699.20 Da
• Isoelectric Point: 5.6454

>AT36138 WP_115316632.1 NZ_AP022561:c1441206-1440877 [Mycolicibacterium aichiense]
MTMARNWRDIRADAIAQGALDAERAGAAREEMREAVQAHRLAEIRKALGHTRQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGQLRIVAEFGDDTVELTA

Nucleotide

• Length: 330 bp

>AT36138 NZ_AP022561:c1441206-1440877 [Mycolicibacterium aichiense]
ATGACCATGGCGCGCAACTGGCGGGACATCCGCGCGGACGCGATCGCGCAGGGTGCCTTGGATGCCGAGCGGGCCGGTGC
GGCGCGTGAGGAGATGCGTGAGGCCGTCCAGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTGGGTCACACCCGCCAGG
CAGACGTTGCAGCTCTCATGGGCGTCTCTCAGGCCCGCGTCTCCAAGCTGGAGAGCGGCGACCTGTCGCACACCGAGTTG
GGCACGCTTCAGGCGTACGTCGCCGCGCTCGGTGGACAGCTTCGGATCGTGGCCGAATTCGGTGACGACACCGTCGAACT
CACCGCCTGA