35983

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4189029..4189287 Replicon chromosome
Accession NZ_AP022533
Organism Escherichia coli strain THO-006

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag JLF32_RS20120 Protein ID WP_000809168.1
Coordinates 4189135..4189287 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4189029..4189086 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF32_RS20105 4184858..4186117 - 1260 WP_000494928.1 hypothetical protein -
JLF32_RS20110 4186246..4187739 - 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
JLF32_RS20115 4187759..4188520 - 762 WP_001274832.1 hypothetical protein -
- 4189029..4189086 - 58 - - Antitoxin
JLF32_RS20120 4189135..4189287 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
JLF32_RS20125 4189392..4190522 - 1131 WP_001118465.1 molecular chaperone DnaJ -
JLF32_RS20130 4190611..4192527 - 1917 WP_000516135.1 molecular chaperone DnaK -
JLF32_RS20135 4192899..4193303 + 405 WP_000843687.1 DUF2541 family protein -
JLF32_RS20140 4193329..4194042 + 714 WP_001102391.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T35983 WP_000809168.1 NZ_AP022533:4189135-4189287 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T35983 NZ_AP022533:4189135-4189287 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT35983 NZ_AP022533:c4189086-4189029 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References