Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3952753..3953551 Replicon chromosome
Accession NZ_AP022533
Organism Escherichia coli strain THO-006

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag JLF32_RS19015 Protein ID WP_000854730.1
Coordinates 3953174..3953551 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag JLF32_RS19010 Protein ID WP_001285481.1
Coordinates 3952753..3953127 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF32_RS18970 3948728..3949180 + 453 WP_000682723.1 hypothetical protein -
JLF32_RS18975 3949298..3949531 + 234 WP_001213776.1 DUF905 family protein -
JLF32_RS18980 3949631..3950452 + 822 WP_001234359.1 DUF945 domain-containing protein -
JLF32_RS18985 3950452..3950697 + 246 WP_001164966.1 hypothetical protein -
JLF32_RS18990 3950791..3951264 + 474 WP_001313575.1 antirestriction protein -
JLF32_RS18995 3951280..3951756 + 477 WP_001313574.1 RadC family protein -
JLF32_RS19000 3951819..3952040 + 222 WP_000692315.1 DUF987 domain-containing protein -
JLF32_RS19005 3952059..3952703 + 645 WP_000086761.1 hypothetical protein -
JLF32_RS19010 3952753..3953127 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JLF32_RS19015 3953174..3953551 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
JLF32_RS19020 3953548..3954040 + 493 Protein_3728 hypothetical protein -
JLF32_RS19025 3954119..3955107 - 989 Protein_3729 IS630 family transposase -
JLF32_RS19030 3955255..3955443 - 189 Protein_3730 IS66 family transposase -
JLF32_RS19035 3955504..3956637 + 1134 WP_000555401.1 IS110-like element ISEc45 family transposase -
JLF32_RS19040 3956891..3958295 - 1405 Protein_3732 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3952753..3963240 10487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T35981 WP_000854730.1 NZ_AP022533:3953174-3953551 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T35981 NZ_AP022533:3953174-3953551 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT35981 WP_001285481.1 NZ_AP022533:3952753-3953127 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT35981 NZ_AP022533:3952753-3953127 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References