Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 84599..85245 Replicon chromosome
Accession NZ_AP022519
Organism Enterobacter cloacae strain STN0717-73

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JLF40_RS00365 Protein ID WP_033147058.1
Coordinates 84895..85245 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JLF40_RS00360 Protein ID WP_023309874.1
Coordinates 84599..84898 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF40_RS00335 80322..81083 + 762 WP_033147062.1 winged helix-turn-helix domain-containing protein -
JLF40_RS00340 81085..81564 + 480 WP_033147061.1 hypothetical protein -
JLF40_RS00345 81754..82692 + 939 WP_047059676.1 helix-turn-helix domain-containing protein -
JLF40_RS00350 82778..83776 + 999 WP_033147060.1 class I SAM-dependent methyltransferase -
JLF40_RS00355 84133..84570 + 438 WP_033147059.1 acetyltransferase -
JLF40_RS00360 84599..84898 - 300 WP_023309874.1 XRE family transcriptional regulator Antitoxin
JLF40_RS00365 84895..85245 - 351 WP_033147058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JLF40_RS00375 86072..87463 + 1392 WP_033147057.1 glycoside-pentoside-hexuronide family transporter -
JLF40_RS00380 87476..89794 + 2319 WP_033147056.1 alpha-xylosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13561.65 Da        Isoelectric Point: 8.0081

>T35887 WP_033147058.1 NZ_AP022519:c85245-84895 [Enterobacter cloacae]
MWTVLFGKVFEQWLLEQEEGLQDKVLADLLNLQKYGPRLPRPYADTVKGSWYNHMKELRIQYAGRPIRAFFAFDPVRQAI
VLCAGDKSNDKAFYEKMIRIADTEFSFHLTSLEATK

Download         Length: 351 bp

>T35887 NZ_AP022519:c85245-84895 [Enterobacter cloacae]
ATGTGGACGGTTCTGTTCGGTAAGGTATTCGAGCAATGGCTGCTTGAACAGGAAGAAGGATTACAGGATAAGGTACTGGC
AGACCTGCTAAATCTGCAAAAATATGGGCCACGTCTTCCACGGCCCTATGCTGATACGGTTAAAGGCTCATGGTATAACC
ATATGAAAGAATTACGTATTCAATATGCTGGACGTCCGATACGTGCTTTCTTCGCATTTGATCCTGTCCGTCAGGCCATT
GTGCTTTGCGCGGGCGATAAGAGTAACGACAAAGCCTTTTATGAAAAAATGATTCGCATCGCAGATACCGAATTTTCCTT
CCATCTGACAAGCCTGGAGGCAACCAAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11165.99 Da        Isoelectric Point: 7.2052

>AT35887 WP_023309874.1 NZ_AP022519:c84898-84599 [Enterobacter cloacae]
VKTLNEVIASRSPESQQRIKEMADEMILETGLQLLREELRLSQKNVADLMGVSQPAVTQLEQRGNELKIATLKRYIEAMG
GKLHIDIELPTGKRVAFHI

Download         Length: 300 bp

>AT35887 NZ_AP022519:c84898-84599 [Enterobacter cloacae]
GTGAAAACCTTAAATGAAGTGATTGCGTCACGTTCACCGGAAAGCCAACAACGTATTAAAGAGATGGCAGATGAAATGAT
CCTCGAGACGGGTCTGCAACTTTTACGTGAAGAGCTGAGACTTTCGCAAAAAAATGTTGCCGATTTGATGGGGGTGAGTC
AGCCCGCAGTAACGCAGCTAGAGCAACGTGGAAATGAACTCAAAATTGCCACGCTTAAGCGCTACATTGAGGCAATGGGG
GGGAAACTTCATATCGATATTGAACTTCCCACAGGAAAACGCGTTGCATTTCATATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References