Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1227019..1227743 Replicon chromosome
Accession NZ_AP022498
Organism Enterobacter kobei strain STN0717-53

Toxin (Protein)


Gene name higB Uniprot ID A0A7I7DX37
Locus tag JLH17_RS05795 Protein ID WP_045268290.1
Coordinates 1227435..1227743 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A7I7DW08
Locus tag JLH17_RS05790 Protein ID WP_045268291.1
Coordinates 1227019..1227438 (-) Length 140 a.a.

Genomic Context


JLH17_RS05755JLH17_RS05760JLH17_RS05765JLH17_RS05770JLH17_RS05775JLH17_RS05800JLH17_RS05815JLH17_RS05780JLH17_RS05785JLH17_RS05790JLH17_RS05795JLH17_RS05805JLH17_RS05810
Location: 1222200..1222757 (558 bp)
Type: Others
Protein ID: WP_052684026.1
Location: 1222922..1223485 (564 bp)
Type: Others
Protein ID: WP_045268304.1
Location: 1223643..1224029 (387 bp)
Type: Others
Protein ID: WP_045268295.1
Location: 1224254..1224781 (528 bp)
Type: Others
Protein ID: Protein_1122
Location: 1224781..1225185 (405 bp)
Type: Others
Protein ID: WP_052684025.1
Location: 1228037..1228825 (789 bp)
Type: Others
Protein ID: WP_045268289.1
Location: 1230706..1231485 (780 bp)
Type: Others
Protein ID: WP_014882917.1
Location: 1225654..1226127 (474 bp)
Type: Others
Protein ID: WP_014882896.1
Location: 1226296..1226886 (591 bp)
Type: Others
Protein ID: WP_045268292.1
Location: 1227019..1227438 (420 bp)
Type: Antitoxin
Protein ID: WP_045268291.1
Location: 1227435..1227743 (309 bp)
Type: Toxin
Protein ID: WP_045268290.1
Location: 1228966..1229421 (456 bp)
Type: Others
Protein ID: WP_023332323.1
Location: 1229719..1230600 (882 bp)
Type: Others
Protein ID: Protein_1130
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JLH17_RS057551222200..1222757+558WP_052684026.1hypothetical protein-
JLH17_RS057601222922..1223485+564WP_045268304.1hypothetical protein-
JLH17_RS057651223643..1224029+387WP_045268295.1hypothetical protein-
JLH17_RS057701224254..1224781+528Protein_1122HNH endonuclease-
JLH17_RS057751224781..1225185+405WP_052684025.1SMI1/KNR4 family protein-
JLH17_RS057801225654..1226127-474WP_014882896.1GNAT family N-acetyltransferase-
JLH17_RS057851226296..1226886-591WP_045268292.1hypothetical protein-
JLH17_RS057901227019..1227438-420WP_045268291.1helix-turn-helix domain-containing proteinAntitoxin
JLH17_RS057951227435..1227743-309WP_045268290.1type II toxin-antitoxin system HigB family toxinToxin
JLH17_RS058001228037..1228825+789WP_045268289.1phosphotransferase-
JLH17_RS058051228966..1229421-456WP_023332323.1hypothetical protein-
JLH17_RS058101229719..1230600-882Protein_1130LysR family transcriptional regulator-
JLH17_RS058151230706..1231485+780WP_014882917.1acetolactate decarboxylase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(22-92)

Antitoxin

(5-137)


Sequences


Toxin        


Download         Length: 103 a.a.        Molecular weight: 11883.64 Da        Isoelectric Point: 8.5216

>T35819 WP_045268290.1 NZ_AP022498:c1227743-1227435 [Enterobacter kobei]
MLAVSRAPFDTATRQFPNHALALDDLYRIQKRSTTRHQTTCESSYLAWLDEISVKMMGIDVGGVHFRVMFFADFERGKIF
IKHISTHAECDKLTDLYRRTKE

Download         Length: 309 bp

>T35819 NZ_AP022498:c1227743-1227435 [Enterobacter kobei]
ATGCTCGCAGTCTCAAGAGCGCCTTTCGACACAGCGACCAGACAATTTCCCAATCATGCACTCGCTCTGGACGATCTTTA
CCGAATACAAAAAAGGAGCACTACCCGTCACCAGACGACATGCGAAAGCTCTTACCTAGCCTGGCTGGATGAAATTTCAG
TAAAAATGATGGGCATTGATGTGGGTGGAGTACATTTTAGAGTAATGTTTTTTGCTGATTTTGAGCGGGGAAAGATCTTC
ATCAAACACATCAGCACACACGCAGAGTGTGACAAGCTCACGGACCTCTACCGCAGAACGAAAGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15502.49 Da        Isoelectric Point: 4.5034

>AT35819 WP_045268291.1 NZ_AP022498:c1227438-1227019 [Enterobacter kobei]
MNYAAAIKAANDLTNELPFLGSSPSRQDYEDALTLVEYLIEHDPDSPLVELLTVKIDKYENESAEFAEFNARFASISSGV
ALLRTLMDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGLPVSAFVGN

Download         Length: 420 bp

>AT35819 NZ_AP022498:c1227438-1227019 [Enterobacter kobei]
ATGAATTATGCAGCAGCCATCAAAGCGGCAAATGATCTGACAAACGAGCTCCCTTTCCTGGGATCAAGCCCGTCACGACA
AGATTATGAGGATGCGCTGACACTTGTGGAGTATCTGATTGAGCATGACCCCGATAGCCCGCTGGTAGAATTGCTCACCG
TCAAAATCGATAAATACGAAAACGAGTCTGCGGAGTTTGCAGAATTTAACGCGCGCTTTGCCAGCATTTCATCTGGAGTT
GCACTGCTGAGAACGCTGATGGATCAGTACCAACTCACTCAGAGCGACTTTGAGAATGAGATTGGCAAGAAGTCTTTGGT
GAGTCGGATCCTCAACGGACAGCGCACGTTAACGCTGGATCATATGCGCGCGCTGGCGAAGCGTTTTGGATTGCCAGTGA
GTGCGTTTGTGGGGAATTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A7I7DX37


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7I7DW08

References